ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >TGF-beta / Smad >TGF-beta / Smad inhibitors >6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

CAS No.: 356559-20-1

Chemical Name:: 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

Synonyms: 100869;CS-474;SB522334;SB-525334;SB 525334, >=98%;SB525334;SB 525334;TGF-β RI Kinase Inhibitor VIII;SB525334 SB-525334 TGF-β RI Kinase Inhibitor VIII;SB-525334;SB 525334;TGF-Β RI KINASE INHIBITOR VIII;TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem

CBNumber:: CB32100545

Molecular Formula:: C21H21N5

Molecular Weight:: 343.42

MOL File:: 356559-20-1.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline Properties

Melting point	159 °C
Boiling point	540.5±45.0 °C(Predicted)
Density	1.191
storage temp.	2-8°C
solubility	DMSO: ≥20mg/mL
pka	10.24±0.10(Predicted)
form	Yellow solid
color	yellow
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey	DKPQHFZUICCZHF-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H315-H319-H335-H413

Precautionary statements

P261-P301+P310-P305+P351+P338

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

RIDADR

UN 2811 6.1/PG 3

WGK Germany

HS Code

2933.39.6190

NFPA 704

	0
2		0

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	S8822	SB-525334 ≥98% (HPLC)	356559-20-1	5MG	₹21152.05	2022-06-14	Buy
Sigma-Aldrich(India)	S8822	SB-525334 ≥98% (HPLC)	356559-20-1	25MG	₹83742.2	2022-06-14	Buy
Sigma-Aldrich(India)	616459	TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem The TGF-β RI Kinase Inhibitor VIII, also referenced under CAS 356559-20-1, controls the biological activity of TGF-β RI Kinase. This small molecule/in	356559-20-1	2MG	₹7070	2022-06-14	Buy
TCI Chemicals (India)	B5776	SB-525334	356559-20-1	10MG	₹5300	2022-05-26	Buy
TCI Chemicals (India)	B5776	SB-525334	356559-20-1	50MG	₹18000	2022-05-26	Buy

Product number	Packaging	Price	Buy
S8822	5MG	₹21152.05	Buy
S8822	25MG	₹83742.2	Buy
616459	2MG	₹7070	Buy
B5776	10MG	₹5300	Buy
B5776	50MG	₹18000	Buy

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline Chemical Properties,Uses,Production

Description

SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC₅₀ = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6. SB-525334 blocks TGF-β1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-β1-directed gene expression. It is effective in vivo, preventing puromycin aminonucleoside-induced renal fibrosis and bleomycin-induced pulmonary fibrosis. SB-525334 also modulates carcinogenesis and suppresses the development of pulmonary arterial hypertension in animals.

Uses

SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 = 14.3 nM.

Biological Activity

Selective inhibitor of transforming growth factor- β receptor I (ALK5, TGF- β RI) (IC 50 = 14.3 nM). Inhibits TGF- β 1-induced smad2/3 nuclear localisation and TGF- β 1-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline Preparation Products And Raw materials

Raw materials

Preparation Products

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline Suppliers

Global( 174)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	25247	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
TCI Chemicals (India) Pvt. Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline Spectrum

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline(356559-20-1)¹HNMR

356559-20-1(6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline)Related Search:

2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride Binimetinib ARRY-424704, ARRY-704 BKM120 (NVP-BKM120, Buparlisib)

MLN0905 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid NVP-BVU 972 Tozasertib R428

Nutlin 3a 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide BMS-794833 SB 431542 LY2109761

GW788388 Ispinesib 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

chevron_left

1of4

chevron_right

SB-525334 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline SB522334 SB525334 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 6-(2-tert-butyl-4-(6-methylpyridin-2-yl)-1H-imidazol-5-yl)quinoxaline 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline SB 525334 SB 525334 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline 6-[2-tert-butyl-4-(6-methyl-2-pyridyl)-4H-imidazol-5-yl]quinoxaline SB 525334, >=98% TGF-β RI Kinase Inhibitor VIII SB525334;SB 525334 100869 TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem CS-474 SB-525334;SB 525334;TGF-Β RI KINASE INHIBITOR VIII 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline or SB525334 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxal Quinoxaline, 6-[2-(1,1-dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]- 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline USP/EP/BP 6-[2-(tert-Butyl)-5-(6-methyl-2-pyridyl)-4-imidazolyl]quinoxaline SB525334 SB-525334 TGF-β RI Kinase Inhibitor VIII inhibit,Inhibitor,SB 525334,TGF-β Receptor,Transforming growth factor beta receptors,SB-525334 356559-20-1 Inhibitors Amines Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Smad TGF-beta