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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Apoptosis >Mdm2 inhibitors > Nutlin 3a

Nutlin 3a

Nutlin 3a Structure
CAS No.
675576-98-4
Chemical Name:
Nutlin 3a
Synonyms
CS-391;Nutlin 3a;(ndash)-Nutlin-3;Nutlin-3a (chiral);Nutlin 3a USP/EP/BP;Nutlin-3a - Nutlin-3, (-)-;MDM2 Antagonist IV, Nutlin-3a;(-)-Nutlin-3|||Nutlin-3a chiral|||(?)-Nutlin-3;4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-
CBNumber:
CB32473892
Molecular Formula:
C30H30Cl2N4O4
Molecular Weight:
581.49
MOL File:
675576-98-4.mol
MSDS File:
SDS
Modify Date:
2024/2/25 14:10:47
Request For Quotation

Nutlin 3a Properties

Density 1.36
storage temp. -20°C
solubility DMSO: soluble5mg/mL, clear
form White powder
pka 14.35±0.20(Predicted)
color white to beige
optical activity [α]/D -140 to -155° (c=0.5, CDCl3)
InChIKey BDUHCSBCVGXTJM-WUFINQPMSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

Nutlin 3a price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0580 Nutlin-3a ≥98% (HPLC) 675576-98-4 5MG ₹30169.8 2022-06-14 Buy
Sigma-Aldrich(India) SML0580 Nutlin-3a ≥98% (HPLC) 675576-98-4 25MG ₹122444.1 2022-06-14 Buy
Product number Packaging Price Buy
SML0580 5MG ₹30169.8 Buy
SML0580 25MG ₹122444.1 Buy

Nutlin 3a Chemical Properties,Uses,Production

Description

Nutlin-3 is a novel small-molecule antagonist of the human homolog of mouse double minute (MDM2) that binds MDM2 in the p53-binding pocket and activates the p53 signaling pathway.

Definition

ChEBI: Nutlin-3 is a stilbenoid. It is a small molecule inhibitor that targets p53-Mdm2 interaction.

Biochem/physiol Actions

Nutlin-3a is a potent nongenotoxic drug. It acts as a tumor suppressor p53 (TP53) activator and stabilizer.

Mode of action

Nutlin-3 binds to the p53 binding pocket in MDM2 and inhibits the p53/MDM2 interaction, leading to stabilization of p53 and induction of p53-dependent cell cycle arrest or apoptosis. Nutlin-3 can also inhibit cancer cell migration and invasion in a p53-dependent manner, most likely through inhibition of RhoA and Rac1 activity. In addition to p53, Nutlin-3 also blocks the interaction of MDM2 with p73, E2F1, HIF-1α, resulting in increased apoptosis (p73, E2F1) and decreased VEGF production and decreased angiogenesis (HIF-1α). Nutlin-3 is predicted to block the interaction of MDM2 and Numb.
Mechanisms of the actions of Nutlin-3
Molecular Mechanisms of the actions of Nutlin-3

References

[1] LYUBOMIR T. VASSILEV. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2[J]. Science, 2004, 303 5659. DOI:10.1126/science.1092472.
[2] YOKO TABE. MDM2 antagonist nutlin-3 displays antiproliferative and proapoptotic activity in mantle cell lymphoma.[J]. Clinical Cancer Research, 2009, 15 3: 933-942. DOI:10.1158/1078-0432.CCR-08-0399.
[3] SHINJI ENDO. Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells[J]. Cancer Science, 2010, 102 3: 605-613. DOI:10.1111/j.1349-7006.2010.01821.x.
[4] HONG SHEN  Carl G M. Pharmacologic activation of p53 by small-molecule MDM2 antagonists.[J]. Current pharmaceutical design, 2011, 17 6: 560-568. DOI:10.2174/138161211795222603.

Nutlin 3a Preparation Products And Raw materials

Raw materials

Preparation Products

Nutlin 3a Suppliers

Global( 155)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
Accela ChemBio Inc. +1-858-6993322 United States 19479 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49392 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29824 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24099 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Labnetwork lnc. +86-27-50766799 +8618062016861 China 19994 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
Accela ChemBio Inc. 58
BOC Sciences 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
Labnetwork lnc. 58
InvivoChem 58

675576-98-4( Nutlin 3a)Related Search:

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6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide BMS-794833 Bortezomib MK-2206 2HCl
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4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone Nutlin 3a Nutlin-3a (chiral) 2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]- 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone Nutlin 3a Nutlin 3a 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2- (ndash)-Nutlin-3 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid MDM2 Antagonist IV, Nutlin-3a 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one Nutlin-3a - Nutlin-3, (-)- CS-391 MDM2 Antagonist IV, Nutlin-3a - CAS 675576-98-4 - Calbiochem Nutlin 3a USP/EP/BP 4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one (-)-Nutlin-3|||Nutlin-3a chiral|||(?)-Nutlin-3 675576-98-4 677576-98-4 Inhibitors