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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >TGF-beta / Smad >TGF-beta / Smad inhibitors >LY2109761

LY2109761

LY2109761 Structure
CAS No.
700874-71-1
Chemical Name:
LY2109761
Synonyms
CS-101;LY210976;LY2109761;LY2109761, >=98%;LY2109761 USP/EP/BP;LY2109761/LY-2109761;N-CYCLOPENTYL-Β-ALANINE;N-CYCLOPENTYL-WEI -ALANINE;LY2109761, 98%, a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor;7-(2-morpholinoethoxy)-4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline
CBNumber:
CB42596729
Molecular Formula:
C26H27N5O2
Molecular Weight:
441.52
MOL File:
700874-71-1.mol
Modify Date:
2024/7/2 8:55:08
Request For Quotation

LY2109761 Properties

Boiling point 640.9±55.0 °C(Predicted)
Density 1.34
storage temp. Store at -20°C
solubility ≥22.1 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form solid
pka 6.27±0.10(Predicted)
color White to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
HS Code  29349990
NFPA 704
0
2 0

LY2109761 Chemical Properties,Uses,Production

Description

LY2157299 is a small molecule inhibitor of the TGF-β receptor type 1/type II kinases (IC50 = 69 nM). It has been used to study the role of TGF-β signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where 5 μM of the compound completely disrupts Smad-2 phosphorylation, an immediate downstream target of the kinase activity. It can also suppress radiation-induced inflammatory cytokine signaling and proangiogenic genes, including ID1, in human primary fibrobalsts.

Uses

LY 2109761 is a novel transforming growth factor beta receptor type I and type II dual inhibitor that is potentially used to treat and suppress pancreatic cancer.

LY2109761 Preparation Products And Raw materials

Raw materials

Morpholine

Preparation Products

LY2109761 Suppliers

Global( 127)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nanjing Doge Biomedical Technology Co., Ltd +86-25-58227606 +86-15305155328 China 4128 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
career henan chemical co 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Nanjing Doge Biomedical Technology Co., Ltd 58

LY2109761 Spectrum

LY2109761(700874-71-1)1HNMR

700874-71-1(LY2109761)Related Search:

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE LY-404039 LY3143921 LY 2606368 LY 379268
LY-2940094 LY 294002 HYDROCHLORIDE xav-939 SB 431542 GW788388
SB525334 PLX4032 LY 2157299
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LY2109761/LY-2109761 LY2109761 Quinoline, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-Morpholinyl)ethoxy]- 4-[5,6-Dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline LY210976 4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]Morpholine N-CYCLOPENTYL-WEI -ALANINE N-CYCLOPENTYL-Β-ALANINE 7-(2-morpholinoethoxy)-4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline 4-[5,6-Dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline LY 2109761 LY2109761, >=98% 4-(2-(4-(2-(Pyridin-2-yl)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yloxy)e LY2109761, 98%, a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor CS-101 LY2109761 USP/EP/BP 700874-71-1 Inhibitors Smad TGF-beta