1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
![1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Structure](CAS/GIF/117690-79-6.gif)
- CAS No.
- 117690-79-6
- Chemical Name:
- 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
- Synonyms
- LY 255283;CGS 23356;LY255283, 10 mM in DMSO;LY255283, BLT2 receptor antagonist;5'-Ethyl-2'-hydroxy-4'-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]acetophenone;1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone;1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE;1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOLE-5-YL)HEPTYL]OXY]PHENYL]-ETHANONE;parcnchyma,LTB4,Leukotriene Receptor,inhibit,BLT2,LY255283,lung,Inhibitor,LY-255283;1-(5-Ethyl-2-hydroxy-4-((6-methyl-6-(2H-tetrazol-5-yl)heptyl)oxy)phenyl)ethan-1-one
- CBNumber:
- CB9257308
- Molecular Formula:
- C19H28N4O3
- Molecular Weight:
- 360.45
- MOL File:
- 117690-79-6.mol
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 160-162 °C |
|---|---|
| Boiling point | 573.4±60.0 °C(Predicted) |
| Density | 1.157±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMSO: >20mg/mL |
| form | powder |
| pka | 5.11±0.10(Predicted) |
| color | off-white to light yellow |
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE price More Price(1)
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Chemical Properties,Uses,Production
Description
Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years. The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100 nM. LY255283 exhibits IC50 values of ~950 nM and >10 μM at human recombinant BLT2 and BLT1 receptors, respectively. LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 μM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260 nM.
Uses
LY-255283 is a selective, competitive BLT2 receptor antagonist used in the treatment of chronic myeloid leukemia.
Biological Activity
Selective, competitive antagonist of BLT 2 receptors (IC 50 values are ~ 1 and > 10 μ M at human recombinant BLT 2 and BLT 1 receptors respectively). Inhibits LTB 4 -induced contraction of lung parenchyma (pA 2 = 7.2), and reduces LTB 4 -mediated airway obstruction in guinea pigs following i.v. and oral administration.
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Preparation Products And Raw materials
Raw materials
Preparation Products
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32249 | 58 | Inquiry |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | China | 3135 | 58 | Inquiry |
| Aladdin Scientific | United States | 57505 | 58 | Inquiry | |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 400-6206333 13167063860 | China | 48458 | 58 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9803 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24759 | 58 | Inquiry |
| 4008-099-669 | CHINA | 73043 | 58 | Inquiry | |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | China | 62072 | 58 | Inquiry |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | China | 4720 | 55 | Inquiry |
| R&D Systems, Inc | 18003437475 18003437475 | China | 35960 | 58 | Inquiry |
117690-79-6(1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE)Related Search:
1of4
chevron_right