1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
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1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 속성
- 녹는점
- 160-162 °C
- 끓는 점
- 573.4±60.0 °C(Predicted)
- 밀도
- 1.157±0.06 g/cm3(Predicted)
- 저장 조건
- Store at +4°C
- 용해도
- DMSO: >20mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 5.11±0.10(Predicted)
- 색상
- 황백색에서 밝은 노란색까지
안전
| WGK 독일 | 2 |
|---|
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE C화학적 특성, 용도, 생산
개요
Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years. The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100 nM. LY255283 exhibits IC50 values of ~950 nM and >10 μM at human recombinant BLT2 and BLT1 receptors, respectively. LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 μM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260 nM.용도
LY-255283 is a selective, competitive BLT2 receptor antagonist used in the treatment of chronic myeloid leukemia.생물학적 활성
Selective, competitive antagonist of BLT 2 receptors (IC 50 values are ~ 1 and > 10 μ M at human recombinant BLT 2 and BLT 1 receptors respectively). Inhibits LTB 4 -induced contraction of lung parenchyma (pA 2 = 7.2), and reduces LTB 4 -mediated airway obstruction in guinea pigs following i.v. and oral administration.1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 준비 용품 및 원자재
원자재
준비 용품
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 공급 업체
글로벌( 58)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 |
sales@chemhifuture.com | China | 3136 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 |
isunpharm@qq.com | China | 4428 | 55 |
| LETOPHARM LIMITED | +86-21-5821 5861 |
sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | |
eric_feng1954@126.com | China | 9254 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9806 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 |
2853530910@QQ.com | China | 8014 | 62 |