1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE

生物活性靶点体外研究体内研究 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 试剂级价格

CAS号:: 117690-79-6

英文名:: 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE

英文别名:: LY 255283;CGS 23356;5'-Ethyl-2'-hydroxy-4'-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]acetophenone;1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone;1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE;1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOLE-5-YL)HEPTYL]OXY]PHENYL]-ETHANONE;parcnchyma,LTB4,Leukotriene Receptor,inhibit,BLT2,LY255283,lung,Inhibitor,LY-255283;1-(5-Ethyl-2-hydroxy-4-((6-methyl-6-(2H-tetrazol-5-yl)heptyl)oxy)phenyl)ethan-1-one;Ethanone, 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(2H-tetrazol-5-yl)heptyl]oxy]phenyl]-

中文名:: 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE

中文别名:: LY255283游离态;化合物LY 255283;LY255283,BLT2受体拮抗剂;1-(5-乙基-2-羟基-4-((6-甲基-6-(2H-四唑-5-基)庚基)氧基)苯基)乙-1-酮

CBNumber:: CB9257308

分子式:: C19H28N4O3

分子量:: 360.45

MOL File:: 117690-79-6.mol

化学性质安全信息用途价格供应商 58

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE化学性质

熔点:: 160-162 °C

沸点:: 573.4±60.0 °C(Predicted)

密度:: 1.157±0.06 g/cm3(Predicted)

储存条件:: Store at +4°C

溶解度:: DMSO: >20mg/mL

形态:: powder

酸度系数(pKa):: 5.11±0.10(Predicted)

颜色:: off-white to light yellow

安全信息

WGK Germany:	2

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE性质、用途与生产工艺

生物活性

LY255283 是一种 leukotriene B4 (LTB4) receptor (BLT2) 的拮抗剂，可将 [3H]LTB4 从其在肺膜上的结合位点置换，pKi为7.0。

靶点

Target	Value
BLT2 (Cell-free assay)	7.0(pKi)

LY255283 competitively reduces conlractilc responses of lung parcnchyma to LTB, (pA ₂ = 7.2).
LY255283 (10 μM, 7 days) significantly suppresses the invasiveness of highly aggressive 253 J-BV bladder cancer cells.

Cell Viability Assay

Cell Line:	253 J-BV cells.
Concentration:	5 or 10 μM.
Incubation Time:	7 days.
Result:	Inhibition of BLT2 signaling attenuates aggressive migration by 253 J-BV cells.

体内研究

LY255283 (3, 30 mg/kg) ameliorates lipopolysaccharide-induced ARDS in pigs, possibly by blocking the recruitment of activated PMNs into alveoli in a dose-dependent fashion.
LY255283 (2.5 mg/kg, ip) inhibits transitional cell carcinoma metastasis in mice models. The result suggests that a BLT2–Nox–ROS–NF–κB cascade plays a critical role in bladder cancer invasion and metastasis.

Animal Model:	Mice (253 J-BV cells injected).
Dosage:	2.5 mg/kg.
Administration:	IP injected 3 and 5 days after injection of cells.
Result:	By 12 weeks after injection, in mice treated with LY255283 only 0-3 nodules formed per lung, and histological analysis confirmed that the number of micrometastatic lesions was markedly reduced.

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 上下游产品信息

上游原料

下游产品

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/04/30	HY-15744	LY255283		1 mg	636元
2024/04/30	HY-15744	1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE LY255283	117690-79-6	5mg	1400元

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 生产厂家

全球有 58家供应商 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
武汉易泰科技有限公司上海分公司	821-50328103-801 18930552037	3bsc@sina.com	中国	15848	69
广州爱纯医药科技有限公司	020-39119399 18927568969	isunpharm@qq.com	中国	4428	55
斯派螺（武汉）药物研发有限公司		eric_feng1954@126.com	中国	9254	55
上海一飞生物科技有限公司	021-65675885 18964387627	info@efebio.com	中国	9708	58
上海瀚香生物科技有限公司	17754423994 17754423994	2853530910@QQ.com	中国	8012	62
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
ChemeGen 中国	18818260767	sales@chemegen.com	中国	11289	58
成都超九八生物科技有限公司	13348960310 13348960310	3003867561@qq.com	中国	10011	58
南通全益生物科技有限公司	18051384581	sales@chemhifuture.com	中国	3059	58
上海毕得医药科技股份有限公司	400-1647117 15221909166	product02@bidepharm.com	中国	63720	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24017	58
上海捷世凯生物科技有限公司	021-57520305 15221441005	guojianing@jskchem.com	中国	49242	58
江苏艾康生物医药研发有限公司	025-66113011 18112977050	cb5@aikonchem.com	中国	10529	58
南京世洲生物科技有限公司	025-85560043 15850508050	cindy.huang@synzest.com	中国	12007	58
上海阿拉丁生化科技股份有限公司	+86-18521732826	market@aladdin-e.com	中国	48467	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	美国	63711	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	美国	57511	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	中国	3136	58
ApexBio技术		sales@apexbt.com	美国	6254	58
美国生物		sales@advtechind.com	美国	6106	58

117690-79-6, 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 相关搜索:

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Prostanoid receptor and related
合成有机化合物配体
C19H28N4O3
LY255283,BLT2受体拮抗剂
1-(5-乙基-2-羟基-4-((6-甲基-6-(2H-四唑-5-基)庚基)氧基)苯基)乙-1-酮
LY255283游离态
化合物LY 255283
117690-79-6
parcnchyma,LTB4,Leukotriene Receptor,inhibit,BLT2,LY255283,lung,Inhibitor,LY-255283
1-(5-Ethyl-2-hydroxy-4-((6-methyl-6-(2H-tetrazol-5-yl)heptyl)oxy)phenyl)ethan-1-one
Ethanone, 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(2H-tetrazol-5-yl)heptyl]oxy]phenyl]-
1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone
CGS 23356
5'-Ethyl-2'-hydroxy-4'-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]acetophenone
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOLE-5-YL)HEPTYL]OXY]PHENYL]-ETHANONE
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
LY 255283