1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
中文名称 | 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE |
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中文同义词 | 化合物LY 255283;LY255283游离态;1-(5-乙基-2-羟基-4-((6-甲基-6-(2H-四唑-5-基)庚基)氧基)苯基)乙-1-酮;LY255283,BLT2受体拮抗剂 |
英文名称 | 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE |
英文同义词 | LY 255283;1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE;1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOLE-5-YL)HEPTYL]OXY]PHENYL]-ETHANONE;5'-Ethyl-2'-hydroxy-4'-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]acetophenone;CGS 23356;1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone;Ethanone, 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(2H-tetrazol-5-yl)heptyl]oxy]phenyl]-;1-(5-Ethyl-2-hydroxy-4-((6-methyl-6-(2H-tetrazol-5-yl)heptyl)oxy)phenyl)ethan-1-one |
CAS号 | 117690-79-6 |
分子式 | C19H28N4O3 |
分子量 | 360.45 |
EINECS号 | |
相关类别 | Prostanoid receptor and related |
Mol文件 | 117690-79-6.mol |
结构式 |
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 性质
熔点 | 160-162 °C |
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沸点 | 573.4±60.0 °C(Predicted) |
密度 | 1.157±0.06 g/cm3(Predicted) |
储存条件 | Store at +4°C |
溶解度 | 二甲基亚砜:>20mg/mL |
形态 | 粉末 |
酸度系数(pKa) | 5.11±0.10(Predicted) |
颜色 | 灰白色至浅黄色 |
Target | Value |
BLT2
(Cell-free assay) | 7.0(pKi) |
LY255283 competitively reduces conlractilc responses of lung parcnchyma to LTB, (pA
2
= 7.2).
LY255283 (10 μM, 7 days) significantly suppresses the invasiveness of highly aggressive 253 J-BV bladder cancer cells.
Cell Viability Assay
Cell Line: | 253 J-BV cells. |
Concentration: | 5 or 10 μM. |
Incubation Time: | 7 days. |
Result: | Inhibition of BLT2 signaling attenuates aggressive migration by 253 J-BV cells. |
LY255283 (3, 30 mg/kg) ameliorates lipopolysaccharide-induced ARDS in pigs, possibly by blocking the recruitment of activated PMNs into alveoli in a dose-dependent fashion.
LY255283 (2.5 mg/kg, ip) inhibits transitional cell carcinoma metastasis in mice models. The result suggests that a BLT2–Nox–ROS–NF–κB cascade plays a critical role in bladder cancer invasion and metastasis.
Animal Model: | Mice (253 J-BV cells injected). |
Dosage: | 2.5 mg/kg. |
Administration: | IP injected 3 and 5 days after injection of cells. |
Result: | By 12 weeks after injection, in mice treated with LY255283 only 0-3 nodules formed per lung, and histological analysis confirmed that the number of micrometastatic lesions was markedly reduced. |
安全信息
WGK Germany | 2 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-15744 | LY255283 | 1 mg | 636元 | |
2024/04/30 | HY-15744 | 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE LY255283 | 117690-79-6 | 5mg | 1400元 |