地诺前列素
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- CAS号:
- 551-11-1
- 英文名:
- Prostaglandin F2a
- 英文别名:
- glandin;u-14583;cyclosin;Dinprost;enzaprost;dinolytic;panacelan;Glandin N;DINOPROST;Dinaprost
- 中文名:
- 地诺前列素
- 中文别名:
- 地诺前列素;前列腺素F2Α;前列腺素 F2a;前列腺素 F2Α;地诺前列素氨丁三醇杂质D;前列腺素F2A/地诺前列素S;地诺前列素/PROSTAGLANDIN F2Α
- CBNumber:
- CB3161368
- 分子式:
- C20H34O5
- 分子量:
- 354.49
- MOL File:
- 551-11-1.mol
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地诺前列素化学性质
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熔点:
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25-35°
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比旋光度:
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D25 +23.5° (c = 1 in tetrahydrofuran)
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沸点:
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407.69°C (rough estimate)
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密度:
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1.0458 (rough estimate)
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折射率:
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1.6120 (estimate)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:100.0(Max Conc. mg/mL);282.1(Max Conc. mM)
Water:100.0(Max Conc. mg/mL);282.1(Max Conc. mM)-
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酸度系数(pKa):
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pKa 4.90(H2O,t=25±2,I=0.0,c<0.01,N2) (Uncertain)
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形态:
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Low melting white solid or colorless oil.
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颜色:
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White to light brown
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InChIKey:
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PXGPLTODNUVGFL-JPYXJAOSNA-N
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SMILES:
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C([C@H]1[C@H](C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCCCC)O)/C=C\CCCC(=O)O |&1:1,2,4,6,9,r|
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CAS 数据库:
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551-11-1(CAS DataBase Reference)
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地诺前列素性质、用途与生产工艺
地诺前列素是天然的前列腺素 F2α (PGF2α),可直接作用于子宫肌层,刺激妊娠子宫使子宫肌收缩,并可使子宫颈变软和扩张,故可用于人工流产和晚期引产。 但是由于地诺前列素的常温下性质不稳定、保存与运输不方便、合成工艺复杂、成本高等局限性,地诺前列素的应用较难普及。加之后来发现米索联合米非司酮可以取得更好的人工流产效果,地诺前列素逐渐淡出人们的视野。
Dinoprost (Prostaglandin F2α) 是一种口服有效的前列腺素 F (PGF) 受体 (FP receptor) 激动剂。Dinoprost 是在子宫内膜腔上皮和黄体 (CL) 中局部产生的溶酶激素。Dinoprost 在分娩过程中起关键作用。
Human Endogenous Metabolite
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FP Receptor
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Dinoprost (Prostaglandin F2α; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells.
Dinoprost (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors.
Apoptosis Analysis
Cell Line:
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Goat luteal cells
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Concentration:
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1 μM
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Incubation Time:
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For 24 hours
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Result:
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Significantly increased the apoptotic rate (15.62±3.12%).
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Cell Autophagy Assay
Cell Line:
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Goat luteal cells
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Concentration:
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1 μM
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Incubation Time:
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For 24 hours
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Result:
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There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells.
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Western Blot Analysis
Cell Line:
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Goat luteal cells
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Concentration:
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1 μM
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Incubation Time:
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For 24 hours
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Result:
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The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.
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地诺前列素
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | P1885 | 前列腺素F2α Prostaglandin F2alpha | 551-11-1 | 1MG | 390元 |
2024/04/30 | HY-12956 | 地诺前列素 Dinoprost | 551-11-1 | 5mg | 550元 |
地诺前列素
生产厂家
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地诺前列素国内生产厂家
551-11-1, 地诺前列素 相关搜索:
- Prostaglandins
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Chiral Reagents
- 医药原料
- 原料药
- 抑制剂
- 生化试剂
- 科研原料
- 医药原料药
- 科研试剂
- 中间体
- 引产药
- 合成
- 前列素类
- 前列腺素类
- 地诺前列素氨丁三醇杂质D
- 地诺前列素/PROSTAGLANDIN F2Α
- 前列腺素F2Α
- 地诺前列素
- 前列腺素 F2a
- 前列腺素 F2Α
- 前列腺素F2A/地诺前列素S
- 551-11-1
- Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9α,11α,13E,15S)-
- 11-epiPGF2α).
- (Z)-7-[(1R,2R,3S,5S)-3,5-dihydroxy-2-[(E)-(3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid (11β-PGF2α
- 2-Methyl-296-nitrobenzyl&chloride
- Prosta-5,13-dien-1-oicacid, 9,11,15-trihydroxy-, (5Z,9a,11a,13E,15S)-
- Prostaglandin F2a USP/EP/BP
- Prostaglandin F2α MaxSpec? Standard
- Prostaglandin F2α
- ProstaglandinF2α>
- PROSTAGLANDIN F2A; PGF2Α
- 4-(3-hydroxyoct-1-enyl)-5-methylcyclopentane-1,3-diol
- PGF2ALPHA
- PROSTAGLANDIN F2ALPHA
- amoglandin
- 9,11,15-trihydroxyprosta-5,13-dien-1-oicacid
- 9,11,15-trihydroxy-,(5z,9alpha,11alpha,13e,15s)-prosta-13-dien-1-oicacid
- 7-[3,5-dihydroxy-2(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoicacid
- 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicacid
- 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicaci(1r-(1
- 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicaci
- 5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-7-(l-5-heptenoicaci
- Dinoprost (Prostaglandin F2a)
- Dinaprost
- 7-[3, 5-dihydroxy-2-(3-hydroxyl-1-octenyl) cyclopentyl]-5-heptenoic acid
- 5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY
- (5z,13e)-(15s)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate
- (5Z,13E)-(15S)-9,11,15-trihydroxyprosta-5,13-dienoate
- (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoic acid
- Dinoprost TroMetaMol(Prostaglandin F2a)
- Prostaglandin F2α Lipid Maps MS Standard
- Prostaglandin F2a/Dinoprost
- 11-epiprostaglandin F2α
- 11-epi-PGF2α
- (5Z,9S,11S,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid