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15(R)-PROSTAGLANDIN E1

15(R)-PROSTAGLANDIN E1 Structure
CAS No.
19313-28-1
Chemical Name:
15(R)-PROSTAGLANDIN E1
Synonyms
PGE0;13,14-dihydro PGE1;Prostaglandin E0 >AlprostadilImpurity5;13,14-Dihydroprostaglandinee1;13,14-DIHYDROPROSTAGLANDIN E1;Prostaglandin E1 Impurity 5 (PGE0);90% (20% solution in ethyl acetate);13,14-Dihydro-prostaglandin E1 (PGE0);9-oxo-11α,15S-dihydroxy-prostan-1-oic acid
CBNumber:
CB2233138
Molecular Formula:
C20H36O5
Molecular Weight:
356.5
MOL File:
19313-28-1.mol
Modify Date:
2023/6/8 9:03:09
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15(R)-PROSTAGLANDIN E1 Properties

Boiling point 541.4±35.0 °C(Predicted)
Density 1.075±0.06 g/cm3(Predicted)
storage temp. Refrigerator, under inert atmosphere
solubility Ethyl Acetate, Methanol, Tetrahydrofuran
form Colorless to pale yellow oil
pka 4.77±0.10(Predicted)
Stability Volatile

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319-H336
Precautionary statements  P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

15(R)-PROSTAGLANDIN E1 Chemical Properties,Uses,Production

Description

13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 value of 40 nM. Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hybrid cells with a Kact value of 668 nM.

Uses

Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and can inhibit aggregation, ATP release, and thromboxane generation by human platelets. Prostaglandin E0 can also decrease the formation of cyclooxygenase (COX) metabolites by inhibiting the induction of COX-2 protein by LPS.

15(R)-PROSTAGLANDIN E1 Preparation Products And Raw materials

Raw materials

Preparation Products

15(R)-PROSTAGLANDIN E1 Suppliers

Global( 40)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Nantong Hanfang Biotechnology Co. , Ltd. 18616537568 China 30968 58 Inquiry
TargetMol Chemicals Inc. 15002134094 China 28118 58 Inquiry
MP Biomedicals, Inc. 949 833 2500 United States 6566 81 Inquiry
Biomol Feinchemikalien GmbH 49-40-8532600 Germany 479 74 Inquiry
BIOMOL INTERNATIONAL, LP (800) 942-0430 United States 1503 77 Inquiry
Service Chemical Inc. 888-895-6920 Germany 6373 71 Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 China 15848 69 Inquiry
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765 China 6457 55 Inquiry
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 China 56057 58 Inquiry
Supplier Advantage
Aladdin Scientific 58
Nantong Hanfang Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
MP Biomedicals, Inc. 81
Biomol Feinchemikalien GmbH 74
BIOMOL INTERNATIONAL, LP 77
Service Chemical Inc. 71
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Shanghai Synchem Pharma Co., ltd 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58

19313-28-1(15(R)-PROSTAGLANDIN E1)Related Search:

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9-OXO-11ALPHA,15S-DIHYDROXY-PROSTAN-1-OIC ACID 13,14-DIHYDROPROSTAGLANDIN E1 PGE0 13,14-Dihydroprostaglandinee1 13,14-dihydro PGE1 7-[(1R,2R,3R)-3-hydroxy-2-[(3S)-3-hydroxyoctyl]-5-oxocyclopentyl]heptanoic acid (11R)-11α,15α-Dihydroxy-9-oxoprostan-1-oic acid 13,14-Dihydro-prostaglandin E1 (PGE0) Prostan-1-oic acid,11,15-dihydroxy-9-oxo-, (11a,15S)- 9-oxo-11α,15S-dihydroxy-prostan-1-oic acid Prostaglandin E0 > 90% (20% solution in ethyl acetate) Prostan-1-oic acid, 11,15-dihydroxy-9-oxo-, (11α,15S)- Prostaglandin E1 Impurity 5 (PGE0) Prostaglandin E0 >90% (20% solution in ethyl acetate) AlprostadilImpurity5 Alprostadil (Prostaglandin E1) Impurity 5 (PGE0) 19313-28-1