Latanoprost
- CAS No.
- 130209-82-4
- Chemical Name:
- Latanoprost
- Synonyms
- 17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER;Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate;xa41;Xalata;phxa41;Latanopros;LATANOPROST;LATANAPROST;Latanoprost>Latanoprost CAS
- CBNumber:
- CB1208384
- Molecular Formula:
- C26H40O5
- Molecular Weight:
- 432.59
- MOL File:
- 130209-82-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/12/13 13:45:59
| alpha | D20 +31.57° (c = 0.91 in acetonitrile) |
|---|---|
| Boiling point | 583.8±50.0 °C(Predicted) |
| Density | 1.093±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: freely soluble |
| form | oil |
| pka | 14.84±0.70(Predicted) |
| color | pale yellow |
| Merck | 14,5376 |
| BCS Class | 2 |
| InChIKey | GGXICVAJURFBLW-RDSJPUOVSA-N |
| CAS DataBase Reference | 130209-82-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H413 | |||||||||
| Precautionary statements | P501-P273 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MJ9669550 | |||||||||
| HS Code | 2937500000 | |||||||||
| NFPA 704 |
|
Latanoprost price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | L1167 | Latanoprost ≥98% (HPLC) | 130209-82-4 | 1MG | ₹14386.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1884 | Latanoprost Pharmaceutical Secondary Standard; Certified Reference Material | 130209-82-4 | 50MG | ₹90875.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L1167 | Latanoprost ≥98% (HPLC) | 130209-82-4 | 5MG | ₹57459.1 | 2022-06-14 | Buy |
| TCI Chemicals (India) | L0262 | Latanoprost | 130209-82-4 | 10MG | ₹9700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | L0262 | Latanoprost | 130209-82-4 | 50MG | ₹21500 | 2022-05-26 | Buy |
Latanoprost Chemical Properties,Uses,Production
Description
Xalatan was launched in Sweden, Switzerland and the US for the treatment of glaucoma. It can be synthesized, from the Corey lactone, using standard prostaglandin chemistry. Latanoprost is a PGF2α, analog that is more lipophilic thus is better able to penetrate the cornea. The (15R)-diastereomer has only 10% of the activity compared to the (15S)-diastereomer. It is a selective FP receptor agonist with little or no effect on the other prostanoid receptors. The antiglaucoma effects are the result of reduced intraocular pressure arising by increasing uveoscleral outflow with little or no effect on trabeculo-canalicular aqueous outflow and no effect on retinal vasculation or permeability of the blood-aqueous barrier. The topical application is sufficient for a single daily dosage and is well tolerated with no detectible conjunctival hyperaemia.
Chemical Properties
Light Yellow Thick Oil
Uses
Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α (17-phenyl-13,14-dihydro PGF2α). It is a prodrug form of the free acid, which is a potent agonist of the FP receptor in the eye. Latanoprost reduces intraocular pressure in glaucoma patients with few side effects. The EC50 value of latanoprost (tested as the free acid) for FP receptors is 3.6 nM.
Definition
ChEBI: A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension.
General Description
Latanoprost (Xalatan) is available as a 0.005% sterileophthalmic solution in a 2.5-mL dispenser bottle.Latanoprost is also marketed as a combination ophthalmicproduct with the β-adrenergic blocking agent, timolol,which apparently enhances IOP-lowering by decreasing theproduction of aqueous humor. Cautions and side effects aresimilar to those for other ophthalmic prostanoids.
Safety Profile
A poison by ingestion and intravenous route. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Latanoprost Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aptus Therapeutics | +91-9966349855 +91-9966349855 | Telangana, India | 19 | 58 | Inquiry |
| Integrum Life Sciences Private Limited | +91-9502471357 +91-9502471357 | Telangana, India | 13 | 58 | Inquiry |
| Flax Laboratories | +91-9867665132 +91-9867665132 | Maharashtra, India | 44 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Chempifine Chemicals | +91-2225667766 +91-2225667766 | Punjab, India | 144 | 58 | Inquiry |
| JAYESH CHEMICALS | +91 9000125615 | Mumbai, India | 21 | 58 | Inquiry |
| CHEMAZON LABORATORIES | +91 9848551964 | Hyderabad, India | 1320 | 58 | Inquiry |
| FDC Limited | +912226782653 | Mumbai, India | 30 | 58 | Inquiry |
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| Laurus Labs Ltd | +91-4066594333 +91-4039804333 | Telangana, India | 50 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Aptus Therapeutics | 58 |
| Integrum Life Sciences Private Limited | 58 |
| Flax Laboratories | 58 |
| Varanous Labs Pvt Ltd | 58 |
| Chempifine Chemicals | 58 |
| JAYESH CHEMICALS | 58 |
| CHEMAZON LABORATORIES | 58 |
| FDC Limited | 58 |
| Honour Lab Limited | 58 |
| Laurus Labs Ltd | 58 |