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Latanoprost

CAS No.: 130209-82-4

Chemical Name:: Latanoprost

Synonyms: 17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER;Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate;xa41;Xalata;phxa41;Latanopros;LATANOPROST;LATANAPROST;Latanoprost>Latanoprost CAS

CBNumber:: CB1208384

Molecular Formula:: C26H40O5

Molecular Weight:: 432.59

MOL File:: 130209-82-4.mol

MSDS File:: SDS

Modify Date:: 2025/4/29 17:45:46

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Latanoprost Properties

alpha	D20 +31.57° (c = 0.91 in acetonitrile)
Boiling point	583.8±50.0 °C(Predicted)
Density	1.093±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: freely soluble
form	oil
pka	14.84±0.70(Predicted)
color	pale yellow
Merck	14,5376
BCS Class	2
InChIKey	GGXICVAJURFBLW-RDSJPUOVSA-N
CAS DataBase Reference	130209-82-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS08

Signal word

Warning

Hazard statements

H413

Precautionary statements

P501-P273

WGK Germany

RTECS

MJ9669550

HS Code

2937500000

NFPA 704

	0
3		0

Latanoprost price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	L1167	Latanoprost ≥98% (HPLC)	130209-82-4	1MG	₹14386.43	2022-06-14	Buy
Sigma-Aldrich(India)	PHR1884	Latanoprost Pharmaceutical Secondary Standard; Certified Reference Material	130209-82-4	50MG	₹90875.88	2022-06-14	Buy
Sigma-Aldrich(India)	L1167	Latanoprost ≥98% (HPLC)	130209-82-4	5MG	₹57459.1	2022-06-14	Buy
TCI Chemicals (India)	L0262	Latanoprost	130209-82-4	10MG	₹9700	2022-05-26	Buy
TCI Chemicals (India)	L0262	Latanoprost	130209-82-4	50MG	₹21500	2022-05-26	Buy

Product number	Packaging	Price	Buy
L1167	1MG	₹14386.43	Buy
PHR1884	50MG	₹90875.88	Buy
L1167	5MG	₹57459.1	Buy
L0262	10MG	₹9700	Buy
L0262	50MG	₹21500	Buy

Latanoprost Chemical Properties,Uses,Production

Description

Xalatan was launched in Sweden, Switzerland and the US for the treatment of glaucoma. It can be synthesized, from the Corey lactone, using standard prostaglandin chemistry. Latanoprost is a PGF_2α, analog that is more lipophilic thus is better able to penetrate the cornea. The (15R)-diastereomer has only 10% of the activity compared to the (15S)-diastereomer. It is a selective FP receptor agonist with little or no effect on the other prostanoid receptors. The antiglaucoma effects are the result of reduced intraocular pressure arising by increasing uveoscleral outflow with little or no effect on trabeculo-canalicular aqueous outflow and no effect on retinal vasculation or permeability of the blood-aqueous barrier. The topical application is sufficient for a single daily dosage and is well tolerated with no detectible conjunctival hyperaemia.

Chemical Properties

Light Yellow Thick Oil

Uses

Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α (17-phenyl-13,14-dihydro PGF2α). It is a prodrug form of the free acid, which is a potent agonist of the FP receptor in the eye. Latanoprost reduces intraocular pressure in glaucoma patients with few side effects. The EC50 value of latanoprost (tested as the free acid) for FP receptors is 3.6 nM.

Definition

ChEBI: A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension.

General Description

Latanoprost (Xalatan) is available as a 0.005% sterileophthalmic solution in a 2.5-mL dispenser bottle.Latanoprost is also marketed as a combination ophthalmicproduct with the β-adrenergic blocking agent, timolol,which apparently enhances IOP-lowering by decreasing theproduction of aqueous humor. Cautions and side effects aresimilar to those for other ophthalmic prostanoids.

Safety Profile

A poison by ingestion and intravenous route. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.

Latanoprost Preparation Products And Raw materials

Raw materials

5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide Dicyclohexylcarbodiimide Lithium chloride Tris(hydroxymethyl)aminomethane 2-Iodopropane

Triethylamine Cesium carbonate Potassium hydroxide Platinum (+)-Diisopinocampheyl chloroborane

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Preparation Products

Latanoprost Suppliers

Global( 579)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Aptus Therapeutics	+91-9966349855 +91-9966349855	Telangana, India	19	58	Inquiry
Integrum Life Sciences Private Limited	+91-9502471357 +91-9502471357	Telangana, India	13	58	Inquiry
Flax Laboratories	+91-9867665132 +91-9867665132	Maharashtra, India	44	58	Inquiry
Varanous Labs Pvt Ltd	+91-7036248882 +91-7036248882	Hyderabad, India	1537	58	Inquiry
FDC Limited	+912226782653	Mumbai, India	30	58	Inquiry
Honour Lab Limited	+919845977466	Telangana, India	164	58	Inquiry
Chempifine Chemicals	+91-2225667766 +91-2225667766	Punjab, India	144	58	Inquiry
JAYESH CHEMICALS	+91 9000125615	Mumbai, India	21	58	Inquiry
Laurus Labs Ltd	+91-4066594333 +91-4039804333	Telangana, India	50	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry

Supplier	Advantage
Aptus Therapeutics	58
Integrum Life Sciences Private Limited	58
Flax Laboratories	58
Varanous Labs Pvt Ltd	58
FDC Limited	58
Honour Lab Limited	58
Chempifine Chemicals	58
JAYESH CHEMICALS	58
Laurus Labs Ltd	58
Ralington Pharma	58

Latanoprost Spectrum

Latanoprost(130209-82-4)¹HNMR

130209-82-4(Latanoprost)Related Search:

LATANOPROST (FREE ACID),LATANOPROST ACID PHENYL VALERATE Diphenyl ether Phenyl salicylate CHLOROPHOSPHONAZO III

Cyclopentyl chloride Prostaglandin E1 2'-Hydroxy-3-phenylpropiophenone Cyclopentane Bromocyclopentane

Propane Solvent Red 43 Prostaglandin E2 LATANOPROST LACTONE DIOL Travoprost

Dorzolamide Hydrochloride Latanoprost Epoxide (Mixture of isoMers) Latanoprost Tris(triethylsilyl) Ether

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ISOPROPYL (5Z, 9A,11A,15R)-9,11,15-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OATE LATANOPROST [1R-[1α(Z)，2β(R^<*>^)，3α，5α]]-7-[3，5-Dihydroxy-2-(3-hydroxy-5-phenyl-pentyl)cyclopentyl]-5-heptenoic acid 1-methylethyl ester Xalata Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoat Latanopros Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate Latanoprost ,98% 9ALPHA,11ALPHA,15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST- cGMP Latanoprost propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate Latanoprost (50 mg) Latanoprost, >=99% Latanoprost API (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptanoic acid 1-methylethyl ester Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-en 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-pentyl)-cyclopentyl]hept-5-enoate Propan-2-yl 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-pentyl)-cyclopentyl]hept-5-enoate LATANOPROST WS & IMPURITY 9ALPHA,11ALPHA,15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OIC ACID, ISOPROPYL ESTER 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROS-5Z-EN-1-OIC ACID, ISOPROPYL ESTER (1r-(1-alpha(z),2-beta(r*),3-alpha,5-alpha))--methylethyleste 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoicaci1 phxa41 xa41 isopropyl (5z,9α,11α,15r)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate LATANAPROST 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, 1-methylethyl ester, (5Z)- (9CI) 5-Heptenoic acid, 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl]-, 1-methylethyl ester, [1R-[1a(Z),2b(R*),3a,5a]]- Lata prostaglandin (Z)-isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate ratanprostaglandin Latanoprost> 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, 1-methylethyl ester, (5Z)- Latanoprost USP/EP/BP Prostaglin Latanoprost Latanoprost (PHXA41, XA34) LatanoprostQ: What is Latanoprost Q: What is the CAS Number of Latanoprost Q: What is the storage condition of Latanoprost Q: What are the applications of Latanoprost Latanoprost (1357475) 17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate Isopropyl (Z)-7-((1S,2S,3S,5R)-3,5-Dihydroxy-2-((S)-3- hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate Latanoprost CAS Propan-2-Yl (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-Hy 9α,11α,15R-trihydroxy-17-phenyl-18,19,20-trinor-prost-5Z-en-1-oic acid, isopropyl ester Latanoprost, 10 mM in DMSO 130209-82-4 30209-82-4 13029-82-4 Prostaglandin Prostaglandins Active Pharmaceutical Ingredients Other APIs Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals