Travoprost
- CAS No.
- 157283-68-6
- Chemical Name:
- Travoprost
- Synonyms
- Trovoprost;Trivo;FLU-IPR;AL 6221;Travatan;ravopros;Travaprost;TRAVOPROST;Trivoprost;Travoprostt
- CBNumber:
- CB5703458
- Molecular Formula:
- C26H35F3O6
- Molecular Weight:
- 500.55
- MOL File:
- 157283-68-6.mol
- Modify Date:
- 2025/1/27 9:38:02
| alpha | D20 +14.6° (c = 1.0 in methylene chloride) |
|---|---|
| Boiling point | 584.8±50.0 °C(Predicted) |
| Density | 1.245±0.06 g/cm3(Predicted) |
| Flash point | 17 °C |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Dichloromethane (Sparingly, Sonicated), Chloroform (Sparingy), Methanol (Sparing |
| form | ethanol solution |
| pka | 13.43±0.20(Predicted) |
| color | Colourless to Light Beige |
| BCS Class | 2 |
| Stability | Light Sensitive |
| InChIKey | MKPLKVHSHYCHOC-AHTXBMBWSA-N |
| CAS DataBase Reference | 157283-68-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P305+P351+P338 | |||||||||
| Hazard Codes | F,Xi | |||||||||
| Risk Statements | 11-36/37/38 | |||||||||
| Safety Statements | 16-26-36-7 | |||||||||
| RIDADR | UN 1170 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| HS Code | 2937500000 | |||||||||
| NFPA 704 |
|
Travoprost Chemical Properties,Uses,Production
Description
Travoprost was launched in the US as Travatan?, an ophthalmic solution (0.004%) administered topically for the treatment of elevated intraocular hypertension (lOP) through open-angle glaucoma, a common optic neuropathy and a leading cause of blindness. Travoprost is the isopropyl ester of (+)-fluprostenol, a new prostaglandin derivative belonging to the PGF2α, analog class. This compound can be prepared in 8 steps from a bicyclic lactone aldehyde by a Wittig alkylidenation followed, after 2 ketonic reductions, by a lactol opening to prostenoic acid while protecting and deprotecting appropriately. Travoprost is a full agonist of FP receptors with a greater affinity than PGF2α, (K1 = 52 nM). Pharmacologic studies in rabbits treated daily for a week demonstrated a significant increase of the microvascular optic nerve head blood flow without significant alterations in the systemic flow. In several placebo-controlled clinical studies with hundreds of patients suffering from open-angle glaucoma or ocular hypertension, travoprost (1 to 4 pm daily) dose-dependently reduced lOP (by about 30% at 4 pm); it was shown equal or superior to latanoprost, another prostaglandin analog (5 pm daily) or the adrenergic ~-blocker timolol (500 pm bid). In addition, travoprost was safe and well tolerated with a low incidence of conjunctival hyperaemia.
Chemical Properties
Colorless Oil
Uses
Travoprost is a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).
Definition
ChEBI: The isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophth lmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the co nea to the biologically active free acid, fluprostenol.
General Description
Travoprost (Travatan and Travatan-Z) is supplied asa 2.5- or 5.0-mL sterile 0.004% ophthalmic solution in a4.0- or 7.5-mL size container. Travoprost is claimed to bethe most potent and FP-specific analog in this product category. Cautions and side effects are similar to those givenpreviously.
Travoprost Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aptus Therapeutics | +91-9966349855 +91-9966349855 | Telangana, India | 19 | 58 | Inquiry |
| Integrum Life Sciences Private Limited | +91-9502471357 +91-9502471357 | Telangana, India | 13 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| Flax Laboratories | +91-9867665132 +91-9867665132 | Maharashtra, India | 44 | 58 | Inquiry |
| ANVI Pharma | +91-2228995761 +91-2228995761 | Maharashtra, India | 10 | 58 | Inquiry |
| Chempifine Chemicals | +91-2225667766 +91-2225667766 | Punjab, India | 144 | 58 | Inquiry |
| Sai Life Sciences Ltd | +91-4066777555 +91-8008555365 | Hyderabad, India | 24 | 58 | Inquiry |
| JAYESH CHEMICALS | +91 9000125615 | Mumbai, India | 21 | 58 | Inquiry |
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| Laurus Labs Ltd | +91-4066594333 +91-4039804333 | Telangana, India | 50 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Aptus Therapeutics | 58 |
| Integrum Life Sciences Private Limited | 58 |
| Dr. Reddy's Laboratories Ltd | 58 |
| Flax Laboratories | 58 |
| ANVI Pharma | 58 |
| Chempifine Chemicals | 58 |
| Sai Life Sciences Ltd | 58 |
| JAYESH CHEMICALS | 58 |
| Honour Lab Limited | 58 |
| Laurus Labs Ltd | 58 |
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