Bimatoprost
- CAS No.
- 155206-00-1
- Chemical Name:
- Bimatoprost
- Synonyms
- Bima;LUMIGAN;bimatoprost powder;N-ETHYL-9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z, 13E-DIEN-1-AMIDE;bimatopros;Bimatoprost (W.S);BiMatoprost HOUSE STANDARD;17-phenyl-tri-norprostaglandin f2α-ethyl amide;17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ETHYL AMIDE;CS-2897
- CBNumber:
- CB0171421
- Molecular Formula:
- C25H37NO4
- Molecular Weight:
- 415.57
- MOL File:
- 155206-00-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/27 13:31:27
| Melting point | 66-68°C |
|---|---|
| Boiling point | 629.8±55.0 °C(Predicted) |
| Density | 1.145±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly) |
| form | solid |
| pka | 14.25±0.20(Predicted) |
| color | White to Off-White |
| BCS Class | 3 |
| Stability | Light Sensitive |
| InChIKey | AQOKCDNYWBIDND-FTOWTWDKSA-N |
| SMILES | C(NCC)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCC1=CC=CC=C1 |
| CAS DataBase Reference | 155206-00-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H360F | |||||||||
| Precautionary statements | P201-P301+P312+P330-P308+P313 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Bimatoprost Chemical Properties,Uses,Production
Description
Bimatoprost was first introduced in the US and Brazil as Lumigan?, an ophthalmic solution (0.03%) for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, a proven risk of glaucomatous visual field loss. Bitamoprost is a new agent belonging to the PGF2α analog class of prostamides launched in this indication after latanoprost, the most efficaceous topical medication currently available. This synthetic fatty acid amide can be prepared by esterification of 17- phenyl-18,19,20-trinorprostaglandin F2α followed by ethylamidation. Bimatoprost, as related prostamides, is devoid of typical activities associated with PGF2,, analogs; it exhibits a unique pharmacological profile in contracting the feline iris sphincter with an EC50 of 34 nM without interacting with any known prostanoid receptors. Thus it mimics the action of endogenous prostamides on specific receptors that lower IOP by increasing aqueous humor outflow through both pressure-insensitive and pressure-sensitive pathways without reducing humor formation. In a 3-month controlled clinical trial of efficacy and safety in patients with elevated IOP, bimatoprost demonstrated lower mean intraocular pressures at every time point throughout the study, as well as a good tolerance and systemic safety profile compared to latanoprost.
Chemical Properties
Crystalline Solid
Uses
Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It ha
General Description
Bimatoprost (Lumigan) is supplied as a sterile 0.03%ophthalmic solution in 2.5- and 5.0-mL sizes. The recommendeddosage of bimatoprost is limited to one drop intothe affected eye once daily in the evening. Increased usagemay decrease its beneficial effect. If used concurrently withother IOP-lowering drugs, a waiting period of 5 minutesshould separate administrations.
Bimatoprost Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Integrum Life Sciences Private Limited | +91-9502471357 +91-9502471357 | Telangana, India | 13 | 58 | Inquiry |
| Aptus Therapeutics | +91-9966349855 +91-9966349855 | Telangana, India | 19 | 58 | Inquiry |
| Flax Laboratories | +91-9867665132 +91-9867665132 | Maharashtra, India | 44 | 58 | Inquiry |
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| Meenaakshi Molecules Pvt Ltd | +91-9121311126 +91-9121311126 | Telangana, India | 45 | 58 | Inquiry |
| Lupin Ltd | +91-8019896181 +91-8019896181 | Maharashtra, India | 93 | 58 | Inquiry |
| FDC Limited | +912226782653 | Mumbai, India | 30 | 58 | Inquiry |
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| ANVI Pharma | +91-2228995761 +91-2228995761 | Maharashtra, India | 10 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Integrum Life Sciences Private Limited | 58 |
| Aptus Therapeutics | 58 |
| Flax Laboratories | 58 |
| GLP Pharma Standards | 58 |
| Meenaakshi Molecules Pvt Ltd | 58 |
| Lupin Ltd | 58 |
| FDC Limited | 58 |
| Honour Lab Limited | 58 |
| HRV Global Life Sciences | 58 |
| ANVI Pharma | 58 |
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