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ChemicalBook > Product Catalogue >API >Hormones and the Endocrine System >Prostaglandin drugs >Bimatoprost

Bimatoprost

Bimatoprost Structure
  • ₹16345.75
  • Product name: Bimatoprost
  • CAS: 155206-00-1
  • MF: C25H37NO4
  • MW: 415.57
  • EINECS:642-890-9
  • MDL Number:MFCD03411999
  • Synonyms:BIMATOPROST;BIMATOPROST(TM);BIMATOPROST(LUMIGAN);(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide;(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-5-heptenamide;Prostamide;17-phenyl-tri-norprostaglandin f2α-ethyl a;cGMP Bimatoprost
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Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberP6740
  • Product description17-Phenyl-tri-norprostaglandin F2α-ethyl amide ≥95%, solid
  • Packaging1MG
  • Price₹16345.75
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) P6740 17-Phenyl-tri-norprostaglandin F2α-ethyl amide ≥95%, solid 1MG ₹16345.75 2022-06-14 Buy

Properties

Melting point :66-68°C
Boiling point :629.8±55.0 °C(Predicted)
Density :1.145±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
form :solid
pka :14.25±0.20(Predicted)
color :White to Off-White
BCS Class :3
Stability :Light Sensitive
InChIKey :AQOKCDNYWBIDND-FTOWTWDKSA-N
SMILES :C(NCC)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCC1=CC=CC=C1
CAS DataBase Reference :155206-00-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P201 Obtain special instructions before use.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

17-phenyl trinor Prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide) is an F-series PG analog which has been approved for use as an ocular hypotensive drug. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 μg/g corneal tissue/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

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