Prostaglandin E2
- CAS No.
- 363-24-6
- Chemical Name:
- Prostaglandin E2
- Synonyms
- PROSTAGLANDIN;DINOPROSTONE;PGE2;dinoproston;Propess;Cervidil;Prepidil;Dinoprostol;Prostaglandin E2 (PGE2);l-pge2
- CBNumber:
- CB8461799
- Molecular Formula:
- C20H32O5
- Molecular Weight:
- 352.47
- MOL File:
- 363-24-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/18 12:04:20
| Melting point | 66-68 °C |
|---|---|
| alpha | -85.5 º (c=1, C2H5OH) |
| Boiling point | 406.07°C (rough estimate) |
| Density | 1.0601 (rough estimate) |
| refractive index | 1.6120 (estimate) |
| storage temp. | -20°C |
| solubility | ethanol: 1 mg/mL |
| form | powder |
| pka | pKa 4.77± 0.09(H2O,t=25±0.1,I=0.1(NaCl)) (Uncertain) |
| color | Clear yellow to amber |
| Water Solubility | insoluble |
| Merck | 14,7877 |
| BRN | 4709356 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | XEYBRNLFEZDVAW-ARSRFYASSA-N |
| CAS DataBase Reference | 363-24-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H360FD | |||||||||
| Precautionary statements | P202-P264-P270-P280-P301+P312-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 60-22-61 | |||||||||
| Safety Statements | 53-22-26-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UK8000000 | |||||||||
| F | 8-10 | |||||||||
| HS Code | 29375000 | |||||||||
| NFPA 704 |
|
Prostaglandin E2 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P5640 | Prostaglandin E2 ≥93% (HPLC), synthetic | 363-24-6 | 1MG | ₹13888.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P5640 | Prostaglandin E2 ≥93% (HPLC), synthetic | 363-24-6 | 5MG | ₹27224.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P6532 | Prostaglandin E2 γ-irradiated, powder, BioXtra, suitable for cell culture | 363-24-6 | 1MG | ₹32215.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P5640 | Prostaglandin E2 ≥93% (HPLC), synthetic | 363-24-6 | 10MG | ₹49470.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P0409 | Prostaglandin E2 synthetic, powder, BioReagent, suitable for cell culture | 363-24-6 | 1MG | ₹24118.1 | 2022-06-14 | Buy |
Prostaglandin E2 Chemical Properties,Uses,Production
Chemical Properties
White to pale yellowish-cream powder. Melting point 64-66°C, specific rotation -61°(26°C, c=1, THF). Easily hydrolyzed at pH<4 or pH>8. Soluble in chloroform, ethyl acetate, methanol, absolute ethanol and other organic solvents, slightly soluble in water.
Uses
The most common and most biologically potent of mammalian prostaglandins. Isolated from sheep prostate. Oxytocic; abortifacient.
Definition
ChEBI: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostagland ns.
World Health Organization (WHO)
Dinoprostone, prostaglandin E2, was introduced into medicine in 1971 and is primarily used for cervical ripening during the induction of labour. It is available in various formulations for oral, parenteral and vaginal administration. Tablets, ampoules and vaginal dosage forms (tablets, pessaries, gel) remain registered in many countries.
General Description
PGE2 Dinoprostone (Prostin E2;Cervidil) is a naturally occurring prostaglandin that is administeredin a single dose of 10 mg by controlled-release(0.3 mg/hr) vaginal insert to induce cervical ripening. Use ofthis agent will potentiate the effects of oxytocin.
Biological Activity
Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP 1 , EP 2 , EP 3 and EP 4 receptors (K d values range between ~ 1-10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis.
Safety Profile
Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human reproductive effects by intravenous, intraplacental, and intravaginal routes: changes in the uterus, cervix and vagina; termination of pregnancy; and changes in ferthty. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Prostaglandin E2 Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANVI Pharma | +91-2228995761 +91-2228995761 | Maharashtra, India | 10 | 58 | Inquiry |
| Aspen Biopharma Labs Pvt Ltd | +91-9248058660 +91-9248058662 | Telangana, India | 234 | 58 | Inquiry |
| Lucent Drugs Pvt Ltd | +91-8187000049 +91-9346111900 | Telangana, India | 11 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Aspen Biopharma Labs Private Limited | 08047620755 | Hyderabad, India | 17 | 58 | Inquiry |
| Virchow Laboratories Limited | 08068979612Ext 383 | Hyderabad, India | 31 | 58 | Inquiry |
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