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Glutathione

Glutathione Structure
CAS No.
70-18-8
Chemical Name:
Glutathione
Synonyms
GSH;L-GLUTATHIONE REDUCED;REDUCED GLUTATHIONE;Glutathion;glutatione;GLUTATHIONE REDUCED FORM;isethion;Glutathione powder;Atomolan;glutatiol
CBNumber:
CB6320803
Molecular Formula:
C10H17N3O6S
Molecular Weight:
307.32
MOL File:
70-18-8.mol
MSDS File:
SDS
Modify Date:
2024/8/21 22:41:43

Glutathione Properties

Melting point 192-195 °C (dec.) (lit.)
Boiling point 754.5±60.0 °C(Predicted)
alpha -16.5 º (c=2, H2O)
Density 1.4482 (rough estimate)
refractive index -17 ° (C=2, H2O)
storage temp. 2-8°C
solubility H2O: 50 mg/mL
form powder
pka pK1 2.12; pK2 3.53; pK3 8.66; pK4 9.12(at 25℃)
color White
PH 3 (10g/l, H2O, 20°C)
Odor Odorless
Water Solubility soluble
Merck 14,4475
BRN 1729812
Sequence H-γ-Glu-Cys-Gly-OH
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey RWSXRVCMGQZWBV-WDSKDSINSA-N
LogP -1.645 (est)
CAS DataBase Reference 70-18-8(CAS DataBase Reference)
EPA Substance Registry System Glutathione (70-18-8)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  68-36/37/38
Safety Statements  24/25-36/37/39-27-26
WGK Germany  2
RTECS  MC0556000
9-23
TSCA  Yes
HS Code  29309070
NFPA 704
0
1 0

Glutathione price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) G4251 L-Glutathione reduced ≥98.0% 70-18-8 10MG ₹2727.9 2022-06-14 Buy
Sigma-Aldrich(India) G6529 L-Glutathione reduced BioXtra, ≥98.0% 70-18-8 1G ₹6450 2022-06-14 Buy
Sigma-Aldrich(India) G6529 L-Glutathione reduced BioXtra, ≥98.0% 70-18-8 5G ₹6670 2022-06-14 Buy
Sigma-Aldrich(India) PHR1359 Glutathione Pharmaceutical Secondary Standard; Certified Reference Material 70-18-8 500MG ₹8919.8 2022-06-14 Buy
Sigma-Aldrich(India) G4251 L-Glutathione reduced ≥98.0% 70-18-8 300MG ₹2976.88 2022-06-14 Buy
Product number Packaging Price Buy
G4251 10MG ₹2727.9 Buy
G6529 1G ₹6450 Buy
G6529 5G ₹6670 Buy
PHR1359 500MG ₹8919.8 Buy
G4251 300MG ₹2976.88 Buy

Glutathione Chemical Properties,Uses,Production

Description

Glutathione (GSH) is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals. GSH serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH is also involved in amino acid transport and maintenance of protein sulfhydryl reduction status. The concentration of GSH ranges from a few micromolar in plasma to several millimolar in tissues such as liver.

Chemical Properties

White cryst. powder

Definition

ChEBI: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.

General Description

Glutathione (GSH) is the most important nonprotein thiol widely distributed in animal tissues, plants, and microorganisms. GSH is also a key determinant of redox signaling and protection against oxidative stress.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Safety Profile

Moderately toxic by intravenous route. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.

Purification Methods

Crystallise L-glutathione from 50% aqueous EtOH, dry it in a vacuum and

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