EC 1.6.4.2
storage temp. | 2-8°C |
---|---|
form | suspension (aqueous) |
color | yellow |
EPA Substance Registry System | Reductase, glutathione (9001-48-3) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H334 |
Precautionary statements | P261-P284-P501 |
Safety Statements | 24/25 |
WGK Germany | 3 |
F | 10 |
EC 1.6.4.2 price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | G3664 | Glutathione Reductase from baker''s yeast (S. cerevisiae) ammonium sulfate suspension, 100-300?units/mg protein (biuret) | 9001-48-3 | 100UNITS | ₹3108 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | G3664 | Glutathione Reductase from baker''s yeast (S. cerevisiae) ammonium sulfate suspension, 100-300?units/mg protein (biuret) | 9001-48-3 | 500UNITS | ₹11222.1 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | G9297 | Glutathione Reductase human buffered aqueous solution, ≥10?units/mg protein, recombinant, expressed in E. coli | 9001-48-3 | 500μG | ₹34809.6 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | G3664 | Glutathione Reductase from baker''s yeast (S. cerevisiae) ammonium sulfate suspension, 100-300?units/mg protein (biuret) | 9001-48-3 | 2500UNITS | ₹42180 | 2022-06-14 | Buy |
EC 1.6.4.2 Chemical Properties,Uses,Production
Uses
Human glutathione reductase has been used in:
- glutathione reductase activity assay
- oxidative stress analysis
- redox assays
General Description
Glutathione reductase (GLR1) exists in mitochondrial and cytoplasmic isoforms. It shares sequence and structural homology to thioredoxin reductase, and is a flavin-containing oxidoreductase. Its active site is composed of a redox-active disulphide, and it requires NADPH for its catalytic activity. It is a widely present enzyme and is found in plants, bacteria, yeast, mice and humans.
Biochem/physiol Actions
Glutathione reductase IGR) is a crucial flavoenzyme in the antioxidant defense system. Reduced glutathione (GSH) is used by glutathione peroxidase to detoxify hydrogen peroxide and in the process is converted to oxidized glutathione (GSSG). The GSSG is then recycled back to GSH by glutathione reductase (GR) using NADPH that is then converted to NADP+. The regenerated GSH is then available to detoxify more hydrogen peroxide. The enzyme uses FAD as a cofactor. GR and glutathione peroxidase may inhibit lipid peroxidation by functioning as antioxidant enzymes in sperm. Glutathione reductase shares a structural motif with a number of other proteins including aspartyl proteases, citrate synthase, EF hands, hemoglobins, lipocalins, and α/β hydrolases. GR is stimulated by melatonin and is reportedly irreversibly inhibited by a number of oxygen radical generating systems.
EC 1.6.4.2 Preparation Products And Raw materials
Raw materials
Preparation Products
EC 1.6.4.2 Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 12962 | 58 | Inquiry |
Nanjing Duly Biotech Co.,Ltd | +undefined18013301590 | China | 2452 | 58 | Inquiry |
LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
Shanghai Mingrunda New Materials Technology Co., Ltd | +86 13482725029 13482725029 | China | 1012 | 58 | Inquiry |
Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | China | 4550 | 62 | Inquiry |
Shanghai Zheyan Biotechnology Co., LTD | 18017610038 18017610038 | China | 5000 | 58 | Inquiry |
Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | China | 16168 | 55 | Inquiry |
Shanghai Yingxin Laboratory Equipment Co., Ltd. | 021-021-59178156 17002132182 | China | 11609 | 58 | Inquiry |
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