L-Glutathione
- CAS No.
- 27025-41-8
- Chemical Name:
- L-Glutathione
- Synonyms
- GSSG;L-GLUTATHIONE OXIDIZED;GLUTATHIONE DISULFIDE;Oxiglutatione;oxidizedglutathione;L-GLUTATHIONE OXIDISED;GSSC;NOV-002;Glutathiol;oxigluthione
- CBNumber:
- CB1200803
- Molecular Formula:
- C20H32N6O12S2
- Molecular Weight:
- 612.63
- MOL File:
- 27025-41-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/28 13:53:21
| Melting point | 178 °C (dec.)(lit.) |
|---|---|
| alpha | -99 º (c=4, water) |
| Density | 1.3688 (rough estimate) |
| refractive index | -105 ° (C=2, H2O) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble |
| form | powder |
| pka | 2.12, 3.59, 8.75, 9.65(at 25℃) |
| color | White to off-white |
| optical activity | -111.016 (H2O) |
| Water Solubility | soluble |
| Merck | 13,4488 |
| BRN | 1718700 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | YPZRWBKMTBYPTK-USZNOCQGSA-N |
| CAS DataBase Reference | 27025-41-8(CAS DataBase Reference) |
| EPA Substance Registry System | Oxiglutatione (27025-41-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25-36/37/39-27-37/39 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | MC0556500 | |||||||||
| HS Code | 29309090 | |||||||||
| Toxicity | mouse,LD50,intravenous,> 2gm/kg (2000mg/kg),Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. | |||||||||
| NFPA 704 |
|
L-Glutathione price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | G6654 | L-Glutathione oxidized BioXtra, ≥98% | 27025-41-8 | 500MG | ₹7815.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G6654 | L-Glutathione oxidized BioXtra, ≥98% | 27025-41-8 | 250MG | ₹8692.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G6654 | L-Glutathione oxidized BioXtra, ≥98% | 27025-41-8 | 1G | ₹14397.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G4501 | L-Glutathione oxidized ≥98%, lyophilized powder | 27025-41-8 | 100MG | ₹4070.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G6654 | L-Glutathione oxidized BioXtra, ≥98% | 27025-41-8 | 5G | ₹43657.23 | 2022-06-14 | Buy |
L-Glutathione Chemical Properties,Uses,Production
Description
L-Glutathione oxidized(GSSG) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of it. It can be used for the research of sickle cells and erythrocytes. The ratio of glutathione (GSH) to oxidised glutathione (GSSG) is a key indicator of cellular oxidative stress. It can be used in the clinical diagnosis and treatment of leukaemia by detecting the level of cellular GSH/GSSG in acute myeloid leukaemia (AML), which is characterised by oxidative stress leading to abnormally low levels of oxidised glutathione, with real-time, dynamic and highly sensitive characteristics[1].
Chemical Properties
White lyophilized powder
Uses
L(-)-Glutathione is a biomarker for fatty liver disease.
Application
L-Glutathione (GSH) has been used in the elution buffer to elute GST (glutathione S-transferase)-fused proteins using glutathione-agarose beads. It has been used to prepare a standard curve for GSH analyses. May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.
Side effects
There have been few studies on the side effects of glutathione use, and as a supplement, no associated side effects have been reported from consuming high glutathione only from diet. However, long-term use of glutathione supplements may reduce zinc levels, and inhaling glutathione can cause breathing problems in some people with mild asthma. In addition, there are concerns that the use of glutathione supplements may cause cramps and bloating or allergic reactions, accompanied by symptoms such as rashes. If you experience any of these side effects, stop taking the supplement and contact your doctor.
Purification Methods
Purify it by recrystallisation from 50% aqueous EtOH. Its solubility in H2O is 5%. Store it at 4o. [Li et al. J Am Chem Soc 76 225 1954, Berse et al. Can J Chem 37 1733 1959, Beilstein 4 IV 3168.]
References
[1] ABBASGHULAM. Construction of Genetically Encoded Biosensors to Monitor Subcellular Compartment-Specific Glutathione Response to Chemotherapeutic Drugs in Acute Myeloid Leukemia Cells.[J]. Analytical Chemistry, 2023, 95 5: 2838-2847. DOI:10.1021/acs.analchem.2c04255.
L-Glutathione Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Allastir Private Limited | +91-9840051621 +91-9791039207 | Tamil Nadu, India | 15 | 58 | Inquiry |
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| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Rashi Pharma Care | 07942541782 | Mumbai, India | 45 | 58 | Inquiry |
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