Arachidonic acid
- CAS No.
- 506-32-1
- Chemical Name:
- Arachidonic acid
- Synonyms
- ARA;Arachidonate;Arachidonic;5,8,11,14-EICOSATETRAENOIC ACID;icosa-5,8,11,14-tetraenoic acid;Arachidonic Acid (peroxide free);(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid;20:4n-6;CIS-5,8,11,14-EICOSATETRAENOIC ACID;Single-Use Arachidonic Acid (peroxide free)
- CBNumber:
- CB8112259
- Molecular Formula:
- C20H32O2
- Molecular Weight:
- 304.47
- MOL File:
- 506-32-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/22 14:06:28
| Melting point | -49 °C (lit.) |
|---|---|
| Boiling point | 169-171 °C/0.15 mmHg (lit.) |
| Density | 0.922 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | ethanol: ≥10 mg/mL |
| pka | 4.75±0.10(Predicted) |
| form | oil |
| color | colorless to light yellow |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Merck | 14,765 |
| BRN | 1713889 |
| Concentration | 1 mCi/ml |
| Solvent | Ethanol under argon |
| Specific Activity | 200-240 Ci/mmol |
| Stability | Light Sensitive, Temperature Sensitive |
| InChIKey | YZXBAPSDXZZRGB-DOFZRALJSA-N |
| LogP | 6.99 |
| CAS DataBase Reference | 506-32-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Arachidonic acid(506-32-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P305+P351+P338 | |||||||||
| Risk Statements | 19 | |||||||||
| Safety Statements | 24/25-19 | |||||||||
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CE6675000 | |||||||||
| F | 8-10-23 | |||||||||
| HS Code | 29161900 | |||||||||
| Toxicity | dns-mus:mmr 10 mg/L CRNGDP 5,1123,84 | |||||||||
| NFPA 704 |
|
Arachidonic acid price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A3611 | Arachidonic acid from non-animal source, ≥98.5% (GC) | 506-32-1 | 10MG | ₹7837.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A3611 | Arachidonic acid from non-animal source, ≥98.5% (GC) | 506-32-1 | 100MG | ₹14667.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SAB1412610 | ANTI-FOXC1 antibody produced in mouse clone 1E11, purified immunoglobulin, buffered aqueous solution | 506-32-1 | 100μG | ₹52347.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A3611 | Arachidonic acid from non-animal source, ≥98.5% (GC) | 506-32-1 | 1G | ₹80137.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A-122 | Arachidonic acid 1.0?mg/mL in ethanol, certified reference material, Cerilliant? | 506-32-1 | 1ML | ₹20388.9 | 2022-06-14 | Buy |
Arachidonic acid Chemical Properties,Uses,Production
Description
Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6). It is the counterpart to the saturated arachidic acid found in peanut oil, (L. arachis – peanut.).
Chemical Properties
In chemical structure, arachidonic acid is a carboxylic acid with a 20-carbon chain and four cis-double bonds; the first double bond is located at the sixth carbon from the omega end.
Some chemistry sources define 'arachidonic acid' to designate any of the eicosatetraenoic acids. However, almost all writings in biology, medicine and nutrition limit the term to all-cis-5,8,11,14- eicosatetraenoic acid.
Uses
Arachidonic Acid is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.
Definition
ChEBI: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.
General Description
A Certified Spiking Solution? suitable for use in mass spectrometry-based fatty acid testing applications such as assessment of cardiovascular disease risk and fatty acid deficiency, and detection and quantification of arachidonic acid in nutraceuticals and dietary supplements. Arachidonic acid (cis-5,8,11,14), sometimes referred to as AA or ARA, is a polyunsaturated omega-6 fatty acid. Studies suggests that ARA as well as other fatty acids can serve as biomarkers for cardiovascular disease, and nutritional and metabolic disorders.
Biological Activity
Endogenous free fatty acid released from phospholipids by phospholipase A 2 . Important cellular signaling mediator and precursor of eicosanoids. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases.
Safety Profile
Poison by intravenous route.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits acridsmoke and irritating fumes.
Carcinogenicity
In vitro and in vivo studies indicate that inhibition of arachidonic acid metabolism inhibits the growth of malignant cells, including head and neck squamous cell carcinoma, and implicates arachadonic acid in facilitating the metastasis of these tumor cells. Arachidonic acid reaction with cyclooxygenase and lipoxygenases yield eicosanoids that can mediate prostate cancer proliferation and enhance both tumor vascularization and metastasis. Cytochrome P450 arachidonic acid epoxygenases promote cell proliferation and inhibit apoptosis in endothelial cells.
Arachidonic acid Preparation Products And Raw materials
Raw materials
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|---|---|---|---|---|---|
| Rxn Chemicals Pvt Ltd | +91 (80) 5535-9566 | New Delhi, India | 88 | 0 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Polychemtech India | 08069013892Ext 604 | Haryana, India | 7 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Oxford laboratories | +91 250 239 0032 | Maharashtra, India | 652 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
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