Docosahexaenoic Acid
- CAS No.
- 6217-54-5
- Chemical Name:
- Docosahexaenoic Acid
- Synonyms
- DHA;doconexent;CIS-4,7,10,13,16,19-DOCOSAHEXAENOIC ACID;DHA algal oil;DOCOSAHEXANOIC ACID;CERVONIC ACID;Single-Use Docosahexaenoic Acid (peroxide free);(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid;zhaoyou;Ropufa 60
- CBNumber:
- CB4128690
- Molecular Formula:
- C22H32O2
- Molecular Weight:
- 328.49
- MOL File:
- 6217-54-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/30 14:17:11
| Melting point | -44°C |
|---|---|
| Boiling point | 446.7±24.0 °C(Predicted) |
| Density | 0.943±0.06 g/cm3(Predicted) |
| refractive index | 1.5030-1.5060 |
| Flash point | 62°C |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated, Sonicated) |
| pka | 4.58±0.10(Predicted) |
| form | Oil |
| color | Clear colorless to light yellow |
| Merck | 14,3398 |
| BRN | 1715505 |
| Stability | Light and Air Sensitive |
| InChIKey | MBMBGCFOFBJSGT-UAYLQDFESA-N |
| LogP | 6.778 (est) |
| CAS DataBase Reference | 6217-54-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Doconexent(6217-54-5) |
| EPA Substance Registry System | Docohexanenoic Acid (6217-54-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P305+P351+P338 | |||||||||
| Safety Statements | 23-24/25 | |||||||||
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10-23 | |||||||||
| HS Code | 29161900 | |||||||||
| NFPA 704 |
|
Docosahexaenoic Acid price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D2534 | cis-4,7,10,13,16,19-Docosahexaenoic acid ≥98% | 6217-54-5 | 25MG | ₹7371.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D2534 | cis-4,7,10,13,16,19-Docosahexaenoic acid ≥98% | 6217-54-5 | 100MG | ₹20394.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D2534 | cis-4,7,10,13,16,19-Docosahexaenoic acid ≥98% | 6217-54-5 | 1G | ₹58541.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D-117 | cis-4,7,10,13,16,19-Docosahexaenoic acid 500?μg/mL in ethanol, certified reference material, Cerilliant? | 6217-54-5 | 1ML | ₹18473.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 53171 | cis-4,7,10,13,16,19-Docosahexaenoic acid analytical standard | 6217-54-5 | 10MG | ₹9883.23 | 2022-06-14 | Buy |
Docosahexaenoic Acid Chemical Properties,Uses,Production
Chemical Properties
Clear Colourless Liquid
Uses
Docosahexaenoic acid is found in fish oils in nature. It is also commercially manufactured from microalgae; Crypthecodinium cohnii and Schizochytrium.
Definition
ChEBI: A docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19.
General Description
An omega-3 fatty acid essential for normal brain growth and
function, docosahexaenoic acid (DHA) plays an important role as a signaling factor in cells for both anti- and pro-inflammatory processes. Levels of docosahexaenoic acid as well as other fatty acids are analyzed by GC/MS or LC-MS/MS methods to monitor patients undergoing diet therapy for mitochondrial or peroxisomal disorders. This Certified Spiking Solution? is suitable for use as starting material in the
preparation of linearity standards, calibrators, or controls in mass spectrometry-based DHA testing applications such as assessment of cardiovascular disease risk and fatty acid deficiency, and detection and quantification of DHA in nutraceuticals and dietary supplements.
Biological Activity
Endogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit A β 1-42 fibrillation and toxicity in vitro .
Purification Methods
Its solubility in CHCl3 is 5%. It has been purified from fish oil by GLC using Ar as mobile phase and EGA as stationary phase with an ionisation detector [UV: Stoffel & Ahrens J Lipid Res 1 139 1959], and via the ester by evaporative "molecular" distillation using a 'continuous molecular still' at 10-4 mm with the highest temperature being 110o and a total contact time with the hot surface being 60sec [Farmer & van den Heuvel J Chem Soc 427 1938]. The methyl ester has b 208-211o/2mm, d4 0.9398, 20 1.5035. nD With Br2 it forms a dodecabromide m ca 240o(dec). Also, the acid was converted to the methyl ester and purified through a three-stage molecular still [as described by Sutton Chem Ind (London) 11383 1953] at 96o, and the rate was adjusted so that one-third of the material was removed each cycle of three distillations. The distillate (numbered 4) (13g) was dissolved in EtOH (100mL containing 8g of KOH) at -70o and set aside for 4hours at 30o with occasional shaking under a vacuum. Water (100mL) was added and the solution was extracted with pentane, washed with HCl, dried (MgSO4), filtered and evaporated to give a clear oil (11.5g) m -44.5o to -44.1o. In the catalytic hydrogenation of the oil six mols of H2 are absorbed and docosanoic acid (behenic acid) is produced with m 79.0-79.3o undepressed with an authentic sample (see docosanoic acid below) [Whitcutt Biochem J 67 60 1957]. [Beilstein 2 IV 1812.]
Docosahexaenoic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Ramsun Bio Organics | +91-9742930655 +91-9742475780 | Karnataka, India | 42 | 58 | Inquiry |
| NK Chemiosys Pvt Ltd | +91-9585456771 +91-9787530913 | Tamil Nadu, India | 17 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Bioorganics & Applied Materials Pvt. Ltd. | 08048250473Ext 567 | Karnataka, India | 46 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| HRV Global Life Sciences Private Limited | 91-40-23554991 | Hyderabad, India | 190 | 58 | Inquiry |
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