9-KETO FLUPROSTENOL

9-KETO FLUPROSTENOL Structure
CAS No.
156406-33-6
Chemical Name:
9-KETO FLUPROSTENOL
Synonyms
9-Keto Fluprostenol;Travoprost Impurity 34;FLUPROSTENOL PROSTAGLANDIN E2;Travoprost Impurity 15(9-keto Fluprostenol);9-OXO-11ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR PROSTA-5Z,13E-DIEN-1-OIC ACID;5-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-5-oxocyclopentyl]-, (5Z)-;5-Heptenoic acid,7-[3-hydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]-5-oxocyclopentyl]-,[1R-[1a(Z),2b(1E,3R*),3a]]- (9CI)
CBNumber:
CB0437130
Molecular Formula:
C23H27F3O6
Molecular Weight:
456.45
MOL File:
156406-33-6.mol
Modify Date:
2023/7/12 16:37:56

9-KETO FLUPROSTENOL Properties

Boiling point 607.6±55.0 °C(Predicted)
Density 1.331±0.06 g/cm3(Predicted)
solubility Ethanol: Miscible; PBS (7.2): 10 mg/ml
pka 4.75±0.10(Predicted)

9-KETO FLUPROSTENOL Chemical Properties,Uses,Production

Description

9-keto Fluprostenol is an analog of prostaglandin E2 (PGE2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. It is anticipated that this analog will have strong affinity for EP receptors and act as a PGE2 agonist. However, no studies on the pharmacology of this compound have been published to date.

Uses

9-keto Fluprostenol is an analog of prostaglandin E2 (PGE2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. It is anticipated that this analog will have strong affinity for EP receptors and act as a PGE2 agonist. However, no studies on the pharmacology of this compound have been published to date.

9-KETO FLUPROSTENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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FLUPROSTENOL PROSTAGLANDIN E2 9-OXO-11ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR PROSTA-5Z,13E-DIEN-1-OIC ACID Travoprost Impurity 15(9-keto Fluprostenol) 5-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-5-oxocyclopentyl]-, (5Z)- Travoprost Impurity 34 5-Heptenoic acid,7-[3-hydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]-5-oxocyclopentyl]-,[1R-[1a(Z),2b(1E,3R*),3a]]- (9CI) 9-Keto Fluprostenol 156406-33-6