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Latanoprost acid

Latanoprost acid Structure
CAS No.
41639-83-2
Chemical Name:
Latanoprost acid
Synonyms
(5Z)-;LAT-FA;LT-Acid;PHXA 85;LATANOPROST ACID;latanoprostfreeaci;LATANOPROST (FREE ACID);LATANOPROSTACID;PHXA 85;Latanoprost Impurity 23;LT-ACID(LATANOPROST ACID)
CBNumber:
CB4208385
Molecular Formula:
C23H34O5
Molecular Weight:
390.51
MOL File:
41639-83-2.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:02:18
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Latanoprost acid Properties

Boiling point 609.1±50.0 °C(Predicted)
Density 1.159±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: freely soluble
pka 4.76±0.10(Predicted)
form Oil
color pale yellow, oil
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
WGK Germany  3
HS Code  2937500000
NFPA 704
3
2 0

Latanoprost acid price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) L1292 Latanoprost acid ≥98% (HPLC) 41639-83-2 1MG ₹14267.35 2022-06-14 Buy
Sigma-Aldrich(India) L1292 Latanoprost acid ≥98% (HPLC) 41639-83-2 5MG ₹56885.38 2022-06-14 Buy
Product number Packaging Price Buy
L1292 1MG ₹14267.35 Buy
L1292 5MG ₹56885.38 Buy

Latanoprost acid Chemical Properties,Uses,Production

Description

Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC50 of 3.6 nM for human FP receptors, which is twice the potency of PGF2α. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.

Chemical Properties

Pale Yellow Oil

Definition

ChEBI: A prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone f rmal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension.

Latanoprost acid Preparation Products And Raw materials

Raw materials

Preparation Products

Latanoprost

Latanoprost acid Suppliers

Global( 121)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
GLP Pharma Standards +91 9866074638 Hyderabad, India 1644 58 Inquiry
Orgamine Chemicals(I) Pvt Ltd +91-9820080281 +91-9820080281 Maharashtra, India 451 58 Inquiry
Aspen Biopharma Labs Pvt Ltd +91-9248058660 +91-9248058662 Telangana, India 234 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Anant Pharmaceuticals Pvt. ltd +91 8550986868 Maharashtra, India 736 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
OCEAN TRADING CORPORATION +91(22) 24921669 New Delhi, India 6211 58 Inquiry
Manus Aktteva +91 (79) 6512-3395 New Delhi, India 581 34 Inquiry
Supplier Advantage
GLP Pharma Standards 58
Orgamine Chemicals(I) Pvt Ltd 58
Aspen Biopharma Labs Pvt Ltd 58
SynZeal Research Pvt Ltd 58
Anant Pharmaceuticals Pvt. ltd 58
Pharma Affiliates 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
OCEAN TRADING CORPORATION 58
Manus Aktteva 34

41639-83-2(Latanoprost acid)Related Search:

Latanoprost Epoxide (Mixture of isoMers) Latanoprost Tris(triethylsilyl) Ether NCX 116 15-KETO LATANOPROST (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid
15(S)-Latanoprost Latanoprost Lactone Diol trans Latanoprost CHLOROPHOSPHONAZO III Prostaglandin E2
Latanoprost Citric acid Ethyl 2-(Chlorosulfonyl)acetate Prostaglandin E1 Folic acid
Ascoric Acid Latanoprost Impurity 1 Latanoprost Impurity (Diphenylphosphine Isopropyl Ester)
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LATANOPROST (FREE ACID) LAT-FA 17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA (5Z,9ALPHA,11ALPHA,15R)-9,11,15-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5-EN-1-OIC ACID 9ALPHA, 11ALPHA, 15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OIC ACID PHXA 85 PhXA 85, (5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid Latanoprost acid,(5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid, PhXA 85 LT-ACID(LATANOPROST ACID) LT-Acid (5z,9α,11α,15r)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid LATANOPROST ACID (5Z)- Latanoprost Related CoMpound E Latanoprost Related Compound E (25 mg) ((Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid) (Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid LT-Acid(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid LATANOPROSTACID;PHXA 85 (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid Latanoprost Impurity 8（Latanoprost Acid） Latanoprost Acid/(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, (5Z)- latanoprostfreeaci Latanoprost Related Compound E ((Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl (1357533) Latanoprost Impurity 23 Latanoprost EP Impurity H Latanoprost EP Impurity H (Latanoprost USP Related Compound E) Latanoprost Acid / Latanoprost Related Compound-E 41639-83-2 7130209-82-4 C26H40O5 C23H35O5 Aromatics, Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals Aromatics Chiral Reagents Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals