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Latanoprost acid

Latanoprost acid Structure
  • ₹14267.35 - ₹56885.38
  • Product name: Latanoprost acid
  • CAS: 41639-83-2
  • MF: C23H34O5
  • MW: 390.51
  • EINECS:
  • MDL Number:MFCD08056084
  • Synonyms:LATANOPROST (FREE ACID);LAT-FA;17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA;(5Z,9ALPHA,11ALPHA,15R)-9,11,15-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5-EN-1-OIC ACID;9ALPHA, 11ALPHA, 15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OIC ACID;PHXA 85;PhXA 85, (5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid;Latanoprost acid,(5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid, PhXA 85
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberL1292
  • Product descriptionLatanoprost acid ≥98% (HPLC)
  • Packaging5MG
  • Price₹56885.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberL1292
  • Product descriptionLatanoprost acid ≥98% (HPLC)
  • Packaging1MG
  • Price₹14267.35
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) L1292 Latanoprost acid ≥98% (HPLC) 5MG ₹56885.38 2022-06-14 Buy
Sigma-Aldrich(India) L1292 Latanoprost acid ≥98% (HPLC) 1MG ₹14267.35 2022-06-14 Buy

Properties

Boiling point :609.1±50.0 °C(Predicted)
Density :1.159±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: freely soluble
pka :4.76±0.10(Predicted)
form :Oil
color :pale yellow, oil
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC50 of 3.6 nM for human FP receptors, which is twice the potency of PGF2α. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.

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Suppliers and manufacturers

Orgamine Chemicals(I) Pvt Ltd Aspen Biopharma Labs Pvt Ltd LANSPHARMA OCEAN TRADING CORPORATION Manus Aktteva SynZeal Research Pvt Ltd Anant Pharmaceuticals Pvt. ltd Pharma Affiliates CLEARSYNTH LABS LTD. Pharmaffiliates Analytics and Synthetics P. Ltd