13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 Structure
CAS No.
5094-14-4
Chemical Name:
13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1
Synonyms
U 21002;13,14-dihydro-15-keto PGE1;CDUVSQMTLOYKTR-ZHALLVOQSA-N;13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1;9,15-dioxo-11α-hydroxy-prostan-1-oic acid;9,15-DIOXO-11ALPHA-HYDROXY-PROSTAN-1-OIC ACID;Prostan-1-oic acid, 11-hydroxy-9,15-dioxo-, (11α)-;15-Keto Prostaglandin E0 DISCONTINUED, OFFER K202056
CBNumber:
CB4190392
Molecular Formula:
C20H34O5
Molecular Weight:
354.49
MOL File:
5094-14-4.mol
Modify Date:
2023/5/18 11:31:17

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 Properties

Boiling point 537.2±35.0 °C(Predicted)
Density 1.072±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly), THF (Slightly)
form Oil
pka 4.77±0.10(Predicted)
color Dark Yellow

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 Chemical Properties,Uses,Production

Description

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity. Steady state plasma concentrations are about 10 pg/ml. 13,14-dihydro-15-keto PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 μM, respectively, compared to PGE1 which has an IC50 of 40 nM.

Uses

15-Keto Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and has been shown to induce arterial thromboresistance in experimental animals and in man, but with several magnitudes higher concentrations than Prostaglandin E1. 15-Keto Prostaglandin E0 is also used as the active ingredient in compositions used for the treatment of external secretion disorders.

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 Preparation Products And Raw materials

Raw materials

Preparation Products

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 9,15-DIOXO-11ALPHA-HYDROXY-PROSTAN-1-OIC ACID CDUVSQMTLOYKTR-ZHALLVOQSA-N 13,14-dihydro-15-keto PGE1 9,15-dioxo-11α-hydroxy-prostan-1-oic acid U 21002 Prostan-1-oic acid, 11-hydroxy-9,15-dioxo-, (11α)- 15-Keto Prostaglandin E0 DISCONTINUED, OFFER K202056 5094-14-4