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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >TGF-beta / Smad >TGF-beta / Smad inhibitors >6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline Structure
  • ₹5300 - ₹83742.2
  • Product name: 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline
  • CAS: 356559-20-1
  • MF: C21H21N5
  • MW: 343.42
  • EINECS:
  • MDL Number:MFCD11045307
  • Synonyms:SB-525334;6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline;6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline;SB522334;SB525334 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline;6-(2-tert-butyl-4-(6-methylpyridin-2-yl)-1H-imidazol-5-yl)quinoxaline;6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline SB 525334;SB 525334 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
Price5 Properties Safety Information Description
5 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 2MG
  • 5MG
  • 10MG
  • 25MG
  • 50MG
  • ManufacturerTCI Chemicals (India)
  • Product numberB5776
  • Product descriptionSB-525334
  • Packaging10MG
  • Price₹5300
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB5776
  • Product descriptionSB-525334
  • Packaging50MG
  • Price₹18000
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number616459
  • Product descriptionTGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem The TGF-β RI Kinase Inhibitor VIII, also referenced under CAS 356559-20-1, controls the biological activity of TGF-β RI Kinase. This small molecule/in
  • Packaging2MG
  • Price₹7070
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberS8822
  • Product descriptionSB-525334 ≥98% (HPLC)
  • Packaging5MG
  • Price₹21152.05
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberS8822
  • Product descriptionSB-525334 ≥98% (HPLC)
  • Packaging25MG
  • Price₹83742.2
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B5776 SB-525334 10MG ₹5300 2022-05-26 Buy
TCI Chemicals (India) B5776 SB-525334 50MG ₹18000 2022-05-26 Buy
Sigma-Aldrich(India) 616459 TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem The TGF-β RI Kinase Inhibitor VIII, also referenced under CAS 356559-20-1, controls the biological activity of TGF-β RI Kinase. This small molecule/in 2MG ₹7070 2022-06-14 Buy
Sigma-Aldrich(India) S8822 SB-525334 ≥98% (HPLC) 5MG ₹21152.05 2022-06-14 Buy
Sigma-Aldrich(India) S8822 SB-525334 ≥98% (HPLC) 25MG ₹83742.2 2022-06-14 Buy

Properties

Melting point :159 °C
Boiling point :540.5±45.0 °C(Predicted)
Density :1.191
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
pka :10.24±0.10(Predicted)
form :Yellow solid
color :yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :DKPQHFZUICCZHF-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6. SB-525334 blocks TGF-β1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-β1-directed gene expression. It is effective in vivo, preventing puromycin aminonucleoside-induced renal fibrosis and bleomycin-induced pulmonary fibrosis. SB-525334 also modulates carcinogenesis and suppresses the development of pulmonary arterial hypertension in animals.

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