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ChemicalBook >> CAS DataBase List >> 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

$28 - $2245.7
Product name: 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline
CAS: 356559-20-1
MF: C21H21N5
MW: 343.42
EINECS:
MDL Number:MFCD11045307
Synonyms:SB-525334;6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline;6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline;SB522334;SB525334 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline;6-(2-tert-butyl-4-(6-methylpyridin-2-yl)-1H-imidazol-5-yl)quinoxaline;6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline SB 525334;SB 525334 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline

Price49 Properties Safety Information Description

49 prices

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Brand

AK Scientific
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Biorbyt Ltd
Biosynth Carbosynth
Cayman Chemical
Chem-Impex
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
Sigma-Aldrich
TCI Chemical
Tocris
TRC

Package

10
1mg
1unit
2mg
5mg
10mg
25mg
50mg
100mg
250mg
500mg
50
1g
10mM(in 1mL DMSO)

ManufacturerAK Scientific
Product numberX7491
Product description6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline
Packaging100mg
Price$293
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product numberX7491
Product description6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline
Packaging250mg
Price$590
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product numberX7491
Product description6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline
Packaging500mg
Price$927
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA187949
Product descriptionSB-525334 98+%
Packaging5mg
Price$43
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA187949
Product descriptionSB-525334 98+%
Packaging10mg
Price$56
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA187949
Product descriptionSB-525334 98+%
Packaging50mg
Price$94
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA187949
Product descriptionSB-525334 98+%
Packaging100mg
Price$150
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA187949
Product descriptionSB-525334 98+%
Packaging250mg
Price$297
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA187949
Product descriptionSB-525334 98+%
Packaging1g
Price$744
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0008600
Product descriptionSB-525334 95.00%
Packaging10MG
Price$260.4
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0008600
Product descriptionSB-525334 95.00%
Packaging1G
Price$1501.5
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA5602
Product descriptionSB525334
Packaging1unit
Price$28
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA5602
Product descriptionSB525334
Packaging5mg
Price$50
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA5602
Product descriptionSB525334
Packaging10mM(in 1mL DMSO)
Price$50
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA5602
Product descriptionSB525334
Packaging25mg
Price$150
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA5602
Product descriptionSB525334
Packaging100mg
Price$480
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
AK Scientific	X7491	6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline	100mg	$293	2021-12-16	Buy
AK Scientific	X7491	6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline	250mg	$590	2021-12-16	Buy
AK Scientific	X7491	6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline	500mg	$927	2021-12-16	Buy
Ambeed	A187949	SB-525334 98+%	5mg	$43	2021-12-16	Buy
Ambeed	A187949	SB-525334 98+%	10mg	$56	2021-12-16	Buy
Ambeed	A187949	SB-525334 98+%	50mg	$94	2021-12-16	Buy
Ambeed	A187949	SB-525334 98+%	100mg	$150	2021-12-16	Buy
Ambeed	A187949	SB-525334 98+%	250mg	$297	2021-12-16	Buy
Ambeed	A187949	SB-525334 98+%	1g	$744	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0008600	SB-525334 95.00%	10MG	$260.4	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0008600	SB-525334 95.00%	1G	$1501.5	2021-12-16	Buy
ApexBio Technology	A5602	SB525334	1unit	$28	2021-12-16	Buy
ApexBio Technology	A5602	SB525334	5mg	$50	2021-12-16	Buy
ApexBio Technology	A5602	SB525334	10mM(in 1mL DMSO)	$50	2021-12-16	Buy
ApexBio Technology	A5602	SB525334	25mg	$150	2021-12-16	Buy
ApexBio Technology	A5602	SB525334	100mg	$480	2021-12-16	Buy

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Properties

Melting point :159 °C
Boiling point :540.5±45.0 °C(Predicted)
Density :1.191
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
pka :10.24±0.10(Predicted)
form :Yellow solid
color :yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :DKPQHFZUICCZHF-UHFFFAOYSA-N

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H301	Toxic if swalloed	Acute toxicity,oral	Category 3	Danger	P264, P270, P301+P310, P321, P330,P405, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning
H413	May cause long lasting harmful effects to aquatic life	Hazardous to the aquatic environment, long-term hazard	Category 4

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6. SB-525334 blocks TGF-β1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-β1-directed gene expression. It is effective in vivo, preventing puromycin aminonucleoside-induced renal fibrosis and bleomycin-induced pulmonary fibrosis. SB-525334 also modulates carcinogenesis and suppresses the development of pulmonary arterial hypertension in animals.

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6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

Properties

Safety Information

Description

Related product price

Suppliers and manufacturers