ALK5 inhibitor II
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- ₹6600 - ₹56874.55
- Product name: ALK5 inhibitor II
- CAS: 446859-33-2
- MF: C17H13N5
- MW: 287.32
- EINECS:
- MDL Number:MFCD09037561
- Synonyms:ALK5 INHIBITOR I;2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE;2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine;SJN 2511;2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine;E 616452;E616452;1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
6 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 2MG
- 5MG
- 25MG
- ManufacturerTCI Chemicals (India)
- Product numberR0224
- Product descriptionRepSox
- Packaging5MG
- Price₹6600
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberR0224
- Product descriptionRepSox
- Packaging25MG
- Price₹19900
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberR0158
- Product descriptionRepSox ≥98% (HPLC)
- Packaging25MG
- Price₹56874.55
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number616452
- Product descriptionTGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC?? = 23 nM and
- Packaging2MG
- Price₹23920.01
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberR0158
- Product descriptionRepSox ≥98% (HPLC)
- Packaging5MG
- Price₹14115.8
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number5.08158
- Product descriptionInSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem
- Packaging5MG
- Price₹12940
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | R0224 | RepSox | 5MG | ₹6600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | R0224 | RepSox | 25MG | ₹19900 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | R0158 | RepSox ≥98% (HPLC) | 25MG | ₹56874.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 616452 | TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC?? = 23 nM and | 2MG | ₹23920.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R0158 | RepSox ≥98% (HPLC) | 5MG | ₹14115.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.08158 | InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem | 5MG | ₹12940 | 2022-06-14 | Buy |
Properties
Melting point :195 °C
Boiling point :501.9±50.0 °C(Predicted)
Density :1.296±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
form :Yellow solid
pka :10.05±0.50(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :LBPKYPYHDKKRFS-UHFFFAOYSA-N
Boiling point :501.9±50.0 °C(Predicted)
Density :1.296±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
form :Yellow solid
pka :10.05±0.50(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :LBPKYPYHDKKRFS-UHFFFAOYSA-N
Safety Information
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Description
ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.More related product prices
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