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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Epigenetics >Histone Methyltransferase Inhibitors >3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-

3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-

3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Structure
  • ₹43610 - ₹160112.58
  • Product name: 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
  • CAS: 120964-45-6
  • MF: C12H15ClN4O3
  • MW: 298.7255
  • EINECS:
  • MDL Number:MFCD18782644
  • Synonyms:3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-;3-Deazaneplanocin A (hydrochloride);3-Deazaneplanocin hydrochloride;DZNep hydrochloride;NSC 617989 hydrochloride;(-)-1-[(1R,4R,5S)-3-(HydroxyMethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aMinoiMidazo[4,5-c]pyridine hydrochloride DZNep hydrochloride;(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride (1:1);1H-Imidazo[4,5-c]pyridine, 3-cyclopentene-1,2-diol deriv.
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 2MG
  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number252790
  • Product descriptionHistone Methyltransferase EZH2 Inhibitor, DZNep - CAS 120964-45-6 - Calbiochem Histone Methyltransferase EZH2 Inhibitor, DZNep, CAS 120964-45-6, is a cell-permeable inhibitor of EZH2-mediated trimethylation of K27 on histone H3.
  • Packaging2MG
  • Price₹43610
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0305
  • Product description3-Deazaneplanocin A hydrochloride ≥97% (HPLC)
  • Packaging1MG
  • Price₹48809.93
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0305
  • Product description3-Deazaneplanocin A hydrochloride ≥97% (HPLC)
  • Packaging5MG
  • Price₹160112.58
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 252790 Histone Methyltransferase EZH2 Inhibitor, DZNep - CAS 120964-45-6 - Calbiochem Histone Methyltransferase EZH2 Inhibitor, DZNep, CAS 120964-45-6, is a cell-permeable inhibitor of EZH2-mediated trimethylation of K27 on histone H3. 2MG ₹43610 2022-06-14 Buy
Sigma-Aldrich(India) SML0305 3-Deazaneplanocin A hydrochloride ≥97% (HPLC) 1MG ₹48809.93 2022-06-14 Buy
Sigma-Aldrich(India) SML0305 3-Deazaneplanocin A hydrochloride ≥97% (HPLC) 5MG ₹160112.58 2022-06-14 Buy

Properties

Melting point :168-169℃
storage temp. :-20°C
solubility :H2O: ≥5mg/mL
form :Tan solid
color :white to beige
Water Solubility :Soluble in water (10mM)
InChIKey :UNSKMHKAFPRFTI-FDKLLANESA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells. 3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase. It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells in a dose-dependent manner (0.2-1 μM). 3-Deazaneplanocin A treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis. When used in combination with the pan-histone deacetylase inhibitor panobinostat (10 mg/kg), 3-deazaneplanocin A’s (1 mg/kg) antileukemic effects are synergistically enhanced in mice implanted with AML cells.

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Suppliers and manufacturers

career henan chemical co
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
₹1.00 /1g
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- CAS:120964-45-6
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