Saracatinib
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- Product name: Saracatinib
- CAS: 379231-04-6
- MF: C27H32ClN5O5
- MW: 542.03
- EINECS:1592732-453-0
- MDL Number:MFCD09832698
- Synonyms:7-[2-[4-Methylpiperazin-1-yl]ethoxy]-5-[[tetrahydropyran-4-yl]oxy]-4-[[6-chloro-2,3-Methylenedioxyphenyl]aMino]quinazoline;(S)-2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetaMide;N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine Saracatinib (AZD0530);Saracatinib N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine;Saracatinib, >=98%;Gemcabene Calcium;saracatinib;N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
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Properties
Melting point :84-89°C
Boiling point :671.2±55.0 °C(Predicted)
Density :1.348
storage temp. :-20°C
solubility :Soluble in DMSO (50 mg/ml) and ethanol (54 mg/mL with warming)
form :solid
pka :7.55±0.10(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Boiling point :671.2±55.0 °C(Predicted)
Density :1.348
storage temp. :-20°C
solubility :Soluble in DMSO (50 mg/ml) and ethanol (54 mg/mL with warming)
form :solid
pka :7.55±0.10(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Saracatinib is a dual inhibitor of the tyrosine kinases c-Src and Abl (IC50 = 2.7 and 30 nM, respectively). It less effectively inhibits other receptor and non-receptor tyrosine kinases as well as assorted serine/threonine kinases. Saracatinib is orally available and blocks cell motility, migration, adhesion, invasion, proliferation, differentiation, and survival. Through its effects on c-Src, it reduces osteoclast bone resorption. Saracatinib also blocks denque virus RNA replication through its effect on Fyn kinase.Related product price
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