Gefitinib
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- ₹4200 - ₹45778.93
- Product name: Gefitinib
- CAS: 184475-35-2
- MF: C22H24ClFN4O3
- MW: 446.9
- EINECS:643-034-7
- MDL Number:MFCD04307832
- Synonyms:N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine Gefitinib;Gefitinib, >=99%;GEFITINIB RELATED COMPOUND;Gefitinib N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;GEFITINIB;n-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;ZD 1839;4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-
4 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- 1G
- 5G
- ManufacturerTCI Chemicals (India)
- Product numberG0546
- Product descriptionGefitinib
- Packaging1G
- Price₹4200
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberG0546
- Product descriptionGefitinib
- Packaging5G
- Price₹11200
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1657
- Product descriptionGefitinib ≥98% (HPLC)
- Packaging10MG
- Price₹11355.43
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1657
- Product descriptionGefitinib ≥98% (HPLC)
- Packaging50MG
- Price₹45778.93
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | G0546 | Gefitinib | 1G | ₹4200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | G0546 | Gefitinib | 5G | ₹11200 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | SML1657 | Gefitinib ≥98% (HPLC) | 10MG | ₹11355.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1657 | Gefitinib ≥98% (HPLC) | 50MG | ₹45778.93 | 2022-06-14 | Buy |
Properties
Melting point :119-1200C
Boiling point :586.8±50.0 °C(Predicted)
Density :1.322±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml).
pka :7.00±0.10(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
CAS DataBase Reference :184475-35-2(CAS DataBase Reference)
Boiling point :586.8±50.0 °C(Predicted)
Density :1.322±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml).
pka :7.00±0.10(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
CAS DataBase Reference :184475-35-2(CAS DataBase Reference)
Safety Information
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Description
Overactivity of the epidermal growth factor receptor-associated tyrosine kinase (EGFR-TK) has been associated with a number of cancers and thus TK inhibitors could be potential therapeutic agents to prevent malignant growth. Gefitinib is a selective EGFR-TK inhibitor that blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50s ranging between 0.2-0.4 μM. By interfering with the intracellular kinase domain, gefitinib prevents EGFR autophosphorylation and prevents downstream signal transduction. Gefitinib has been used to treat advanced (or recurrent) non-small cell lung cancer. However, the FDA retracted its general approval for this compound (Iressa?) when a phase III trial failed to demonstrate an overall survival benefit. Gefitinib appears to be most efficacious in treating certain EGFR gene mutations that are prevalent in Asian populations.More related product prices
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