TYRPHOSTIN AG 1296
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- Product name: TYRPHOSTIN AG 1296
- CAS: 146535-11-7
- MF: C16H14N2O2
- MW: 266.29
- EINECS:
- MDL Number:MFCD00270913
- Synonyms:TYRPHOSTIN AG 1296;AG 1296;6,7-DIMETHOXY-2-PHENYLQUINOXALINE;6,7-DIMETHOXY-3-PHENYLQUINOXALINE;Quinoxaline,6,7-dimethoxy-2-phenyl-;AG-1296;AG 1296;;AG 1296 - CAS 146535-11-7 - Calbiochem;AG-1296 (Tyrphostin AG 1296)
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Properties
Boiling point :420.2±40.0 °C(Predicted)
Density :1.192±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO.
pka :0.48±0.30(Predicted)
form :White solid
color :Yellow
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Density :1.192±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO.
pka :0.48±0.30(Predicted)
form :White solid
color :Yellow
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
AG-1296 is a potent and selective inhibitor of PDGFR kinase (IC50= 0.4 μM) both in vitro and in cells (Swiss 3T3 cells). This compound also inhibits Bek (FGF receptor) tyrosine kinase and c-kit. Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype. It also induces apoptosis in a small-cell lung cancer cell line (H526). AG-1296 is an inhibitor of Tyrosine Kinase. AG-1296 is an inhibitor of PDGFR-α and PDGFR-β.Related product price
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