TYRPHOSTIN A25
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- Product name: TYRPHOSTIN A25
- CAS: 118409-58-8
- MF: C10H6N2O3
- MW: 202.17
- EINECS:
- MDL Number:MFCD00133900
- Synonyms:[3,4,5-TRIHYDROXYBENZYLIDENE]MALONONITRILE;AG 82;ALPHA-CYANO-(3,4,5-TRIHYDROXY)CINNAMONITRILE;RG-50875;RARECHEM AL BX 0070;TYRPHOSTIN 25;TYRPHOSTIN RG 50875;TYRPHOSTIN AG 82
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Properties
Melting point :~220°C dec.
Boiling point :500.8±50.0 °C(Predicted)
Density :1.569±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >50 mg/mL, clear, yellow to orange
form :Dark yellow solid
pka :7.10±0.23(Predicted)
color :Yellow Green
Stability :Light Sensitive
CAS DataBase Reference :118409-58-8
Boiling point :500.8±50.0 °C(Predicted)
Density :1.569±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >50 mg/mL, clear, yellow to orange
form :Dark yellow solid
pka :7.10±0.23(Predicted)
color :Yellow Green
Stability :Light Sensitive
CAS DataBase Reference :118409-58-8
Safety Information
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Description
Tyrphostin A25 is a cell-permeable, competitive and reversible inhibitor of substrate binding on protein tyrosine kinases. In cultured rat hepatocytes, Tyrphostin A25 has been shown to inhibit endocytosis of tyramine-cellobiose-asialoorosomucoid (TC-AOM). It has also shown to inhibit neuromedin B-induced phosphorylation of focal adhesion kinase (p125FAK). Inhibits EGFR (epidermal growth factor receptor) tyrosine kinase (IC50=3 M ) and the GTPase activity of transducin. In small cell lung cancer cells tyrphostin A25 has been observed to obstruct neuropeptide and basal stimulated growth. In addition it has blocked the induction of inducible NO synthase in glial cells and in human leukemic cell lines has induced apoptosis.More related product prices
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Suppliers and manufacturers
Pharmaffiliates Analytics and Synthetics P. Ltd
CLEARSYNTH LABS LTD.
Dideu Industries Group Limited
MedBioPharmaceutical Technology Inc
TargetMol Chemicals Inc.
Cayman Chemical Company
Shanghai EFE Biological Technology Co., Ltd.
Shaoguan Qicheng Biotechnology Co., Ltd
Hefei Mokai Pharmaceutical Technology Co., Ltd
Beijing Haite lesk Technology Co., Ltd