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ChemicalBook > Product Catalogue >Biochemical Engineering >Amino Acids and Derivatives >Tyrosine derivatives >TYRPHOSTIN AG 126

TYRPHOSTIN AG 126

TYRPHOSTIN AG 126 Structure
  • ₹17860
  • Product name: TYRPHOSTIN AG 126
  • CAS: 118409-62-4
  • MF: C10H5N3O3
  • MW: 215.16
  • EINECS:
  • MDL Number:MFCD00236448
  • Synonyms:RARECHEM AL BX 0673;TYRPHOSTIN A10;TYRPHOSTIN AG 126;ag127 ;AG 126;ALPHA-CYANO-(3-HYDROXY-4-NITRO)CINNAMONITRILE;[3-HYDROXY-4-NITROBENZYLIDENE]MALONONITRILE;Tyrphostin 126
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number658452
  • Product descriptionAG 126 - CAS 118409-62-4 - Calbiochem A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.
  • Packaging5MG
  • Price₹17860
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 658452 AG 126 - CAS 118409-62-4 - Calbiochem A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. 5MG ₹17860 2022-06-14 Buy

Properties

storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≤0.15mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
form :Yellow solid
color :Light yellow to yellow
Sensitive :Light Sensitive

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

Tyrphostins are a family of protein tyrosine kinase inhibitors originally developed to inhibit cell growth by blocking the activity of certain growth factor receptor kinases (GFRK). The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 is a poor inhibitor of epidermal GFRK (IC50 = 450 μM) and platelet-derived GFRK (IC50 > 100 μM).

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