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ChemicalBook > Product Catalogue >Biochemical Engineering >Amino Acids and Derivatives >Tyrosine derivatives >TYRPHOSTIN A51

TYRPHOSTIN A51

TYRPHOSTIN A51 Structure
  • ₹0
  • Product name: TYRPHOSTIN A51
  • CAS: 122520-90-5
  • MF: C13H8N4O3
  • MW: 268.23
  • EINECS:
  • MDL Number:MFCD00133903
  • Synonyms:AG 183;3-AMINO-2,4-DICYANO-5-(3',4',5'-TRIHYDROXYPHENYL)PENTA-2,4-DIENONITRILE;TYRPHOSTIN AG 183;TYRPHOSTIN A51;TYRPHOSTIN 51;2-AMINO-1,1,3-TRICYANO-4-[3',4',5'-TRIHYDROXYPHENYL]BUTADIENE;2-AMINO-4-(3',4',5'-TRIHYDROXYPHENYL)-1,1,3-TRICYANOBUTA-1,3-DIENE;1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (Z)-
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :275 °C
Boiling point :788.2±60.0 °C(Predicted)
Density :1.591±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form :Orange solid.
pka :8.46±0.15(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

Tyrphostin 51 is a potent inhibitor of EGFR (EGF receptor) kinase activity (IC50=0.8 μM). Inhibition is mixed competitive with ATP and substrate.

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