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ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Tyrosine derivatives >TYRPHOSTIN A51

TYRPHOSTIN A51

TYRPHOSTIN A51 Structure
CAS No.
122520-90-5
Chemical Name:
TYRPHOSTIN A51
Synonyms
AG 183;TYRPHOSTIN 51;TYRPHOSTIN A51;TYRPHOSTIN AG 183;TYRPHOSTIN A51 99+%;Tyrphostin 51(AG-183);TYRPHOSTIN A51 USP/EP/BP;2-AMINO-1,1,3-TRICYANO-4-[3',4',5'-TRIHYDROXYPHENYL]BUTADIENE;2-AMINO-4-(3',4',5'-TRIHYDROXYPHENYL)-1,1,3-TRICYANOBUTA-1,3-DIENE;3-AMINO-2,4-DICYANO-5-(3',4',5'-TRIHYDROXYPHENYL)PENTA-2,4-DIENONITRILE
CBNumber:
CB8260628
Molecular Formula:
C13H8N4O3
Molecular Weight:
268.23
MOL File:
122520-90-5.mol
Modify Date:
2023/5/18 11:31:14
Request For Quotation

TYRPHOSTIN A51 Properties

Melting point 275 °C
Boiling point 788.2±60.0 °C(Predicted)
Density 1.591±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form Orange solid.
pka 8.46±0.15(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Hazard statements  H302-H312-H315-H319-H332-H335
Precautionary statements  P261-P280-P304+P340-P305+P351+P338-P405-P501a
WGK Germany  3
HazardClass  6.1

TYRPHOSTIN A51 Chemical Properties,Uses,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 0.8 μM in the human epidermoid carcinoma cell line A431.

Uses

Tyrphostin 51 is a potent inhibitor of EGFRK activity showing mixed competitive inhibition with ATP and substrate1-3..

TYRPHOSTIN A51 Preparation Products And Raw materials

Raw materials

Preparation Products

TYRPHOSTIN A51 Suppliers

Global( 58)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24639 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
SHANGHAI ZZBIO CO., LTD. 13916577892 19921389125 China 12063 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9274 58 Inquiry
Beijing Lebo Biotechnology Co., Ltd. 010-50934026 CHINA 6057 58 Inquiry
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 China 8141 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 23963 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Beiwanta Biotechnology Co., Ltd. 021-67187366 19901745723 China 9255 58 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9707 58 Inquiry
Supplier Advantage
Dideu Industries Group Limited 58
Aladdin Scientific 58
SHANGHAI ZZBIO CO., LTD. 58
RD International Technology Co., Limited 58
Beijing Lebo Biotechnology Co., Ltd. 58
MedBioPharmaceutical Technology Inc 58
TargetMol Chemicals Inc. 58
Cayman Chemical Company 81
Shanghai Beiwanta Biotechnology Co., Ltd. 58
Shanghai EFE Biological Technology Co., Ltd. 58

122520-90-5(TYRPHOSTIN A51)Related Search:

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AG 183 3-AMINO-2,4-DICYANO-5-(3',4',5'-TRIHYDROXYPHENYL)PENTA-2,4-DIENONITRILE TYRPHOSTIN AG 183 TYRPHOSTIN A51 TYRPHOSTIN 51 2-AMINO-1,1,3-TRICYANO-4-[3',4',5'-TRIHYDROXYPHENYL]BUTADIENE 2-AMINO-4-(3',4',5'-TRIHYDROXYPHENYL)-1,1,3-TRICYANOBUTA-1,3-DIENE 1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (Z)- TYRPHOSTIN A51 99+% 1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (3Z)- TYRPHOSTIN A51 USP/EP/BP Tyrphostin 51(AG-183) 122520-90-5 C13H8N4O3 BioChemical Cell Biology Cell Signaling and Neuroscience Epidermal Growth Factor Receptor (EGFR) Kinase/Phosphatase Biology Receptor Tyrosine Kinase Inhibitors