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ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Tyrosine derivatives >AG 213

AG 213

AG 213 Structure
CAS No.
122520-86-9
Chemical Name:
AG 213
Synonyms
AG 213;RG-50864;TYRPHOSTIN 47;TYRPHOSTIN A47;AG 213 USP/EP/BP;TYRPHOSTIN AG 213;TYRPHOSTIN RG 50864;TYRPHOSTIN A47 99+%;AG 213 (Tyrphostin AG 213);ZGHQGWOETPXKLY-XVNBXDOJSA-N
CBNumber:
CB5152917
Molecular Formula:
C10H8N2O2S
Molecular Weight:
220.25
MOL File:
122520-86-9.mol
Modify Date:
2023/5/18 11:31:21
Request For Quotation

AG 213 Properties

Melting point 213 °C
Boiling point 474.5±55.0 °C(Predicted)
Density 1.512±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 50 mg/mL, clear, orange
pka 8.82±0.10(Predicted)
form Orange solid.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
F  10

AG 213 Chemical Properties,Uses,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 2.4 μM in the human epidermoid carcinoma cell line A431.

Uses

Tyrphostin 47 is a potent inhibitor of EGFR kinase activity.

Biological Activity

Epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC 50 values are 2.4 and 3 μ M respectively). Stimulates microtubule polymerization and promotes neurite outgrowth > 17-fold over basal conditions in vitro . Also weakly inhibits protein kinase C (IC 50 = 60 μ M).

AG 213 Preparation Products And Raw materials

Raw materials

Preparation Products

AG 213 Suppliers

Global( 47)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25655 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9294 58 Inquiry
SHANGHAI ZZBIO CO., LTD. 19921389125 19921389125 China 12065 58 Inquiry
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 China 8141 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Beiwanta Biotechnology Co., Ltd. 021-67187366 19901745723 China 9251 58 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9707 58 Inquiry
American Custom Chemicals Corporation 858 201 6118 United States 6826 51 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Dideu Industries Group Limited 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
SHANGHAI ZZBIO CO., LTD. 58
MedBioPharmaceutical Technology Inc 58
Cayman Chemical Company 81
Shanghai Beiwanta Biotechnology Co., Ltd. 58
Shanghai EFE Biological Technology Co., Ltd. 58
American Custom Chemicals Corporation 51

122520-86-9(AG 213)Related Search:

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ALPHA-CYANO-3,4-DIHYDROXYTHIOCINNAMAMIDE ALPHA-CYANO-(3,4-DIHYDROXY)THIOCINNAMIDE AG 213 3,4-DIHYDROXY-ALPHA-CYANOTHIOCINNAMAMIDE (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-2-PROPENTHIOAMIDE TYRPHOSTIN A47 99+% AG 213 (Tyrphostin AG 213) TYRPHOSTIN 47 TYRPHOSTIN A47 TYRPHOSTIN AG 213 TYRPHOSTIN RG 50864 RG-50864 ZGHQGWOETPXKLY-XVNBXDOJSA-N 3-amino-2-[(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile AG 213 USP/EP/BP 2-Propenethioamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- 122520-86-9 Cell Biology Cell Signaling and Neuroscience BioChemical Biochemicals and Reagents Substrate Analogs Receptor Tyrosine Kinase Inhibitors Epidermal Growth Factor Receptor (EGFR) Enzymes, Inhibitors, and Substrates Enzyme Inhibitors by Type Enzyme Inhibitors Kinase/Phosphatase Biology Intracellular Signaling Protein Kinase