Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Tyrosine derivatives >AG 1478

AG 1478

AG 1478 Structure
CAS No.
175178-82-2
Chemical Name:
AG 1478
Synonyms
AG 1517;AG 1478;SU 5271;WHI-P 79;NSC 669364;PD-153,035;COMPOUND 32;Tyrphostin AG;AG 1478 USP/EP/BP;TYRPHOSTIN AG 1517
CBNumber:
CB8751920
Molecular Formula:
C16H14ClN3O2
Molecular Weight:
315.75
MOL File:
175178-82-2.mol
MSDS File:
SDS
Modify Date:
2025/1/27 9:38:02
Request For Quotation

AG 1478 Properties

Melting point 180 - 183°C
storage temp. 2-8°C
solubility 0.1 M HCl: soluble <0.4 mg/mL
form Pale yellow solid
color Off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

WGK Germany  3
NFPA 704
1
2 0

AG 1478 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) T4182 Tyrphostin AG 1478 ≥98% 175178-82-2 1MG ₹8447.1 2022-06-14 Buy
Sigma-Aldrich(India) T4182 Tyrphostin AG 1478 ≥98% 175178-82-2 5MG ₹28027.5 2022-06-14 Buy
Sigma-Aldrich(India) 658552 AG 1478 - CAS 175178-82-2 - Calbiochem A cell-permeable, reversible, ATP-competitive, highly potent and selective inhibitor of epidermal growth factor receptor kinase versus HER2-neu and pl 175178-82-2 5MG ₹14460.01 2022-06-14 Buy
Sigma-Aldrich(India) 658548 InSolution AG 1478 - CAS 175178-82-2 - Calbiochem 175178-82-2 1MG ₹9490 2022-06-14 Buy
Product number Packaging Price Buy
T4182 1MG ₹8447.1 Buy
T4182 5MG ₹28027.5 Buy
658552 5MG ₹14460.01 Buy
658548 1MG ₹9490 Buy

AG 1478 Chemical Properties,Uses,Production

Uses

Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.

General Description

Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC50 >100 μM), the platelet-derived growth factor (PDGF) receptor (IC50 >100 μM), and p210Bcr-Abl (IC50 >50 μM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.

Biochem/physiol Actions

Primary TargetEpidermal growth factor receptor kinase

AG 1478 Preparation Products And Raw materials

Raw materials

Preparation Products

AG 1478 Suppliers

Global( 126)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49732 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22855 58 Inquiry
DAYANG CHEM (HANGZHOU) CO.,LTD +8617705817739 China 53881 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131957 58 Inquiry
Beijing Dakco is Biotechnology Co., Ltd. 010-64828744 15601365316 CHINA 6348 58 Inquiry
Beijing Xiangsheng Xingye Technology Co., Ltd. 0136-81184382 13681184382 CHINA 5130 58 Inquiry
Shenzhen Xinbosheng Biological Technology Co., Ltd. 0755-26755892 CHINA 6151 58 Inquiry
Shanghai Boyi Biotechnology Co., Ltd. 021-58351080 15800446246 CHINA 5416 58 Inquiry
Shanghai Jijin Chemical Technology Co., Ltd. 400-002-6926 15900443528 CHINA 6606 58 Inquiry
Beijing Baiao Innovation Technology Co., Ltd. 010-5718533 13366620421 CHINA 6002 58 Inquiry
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 58
Dideu Industries Group Limited 58
DAYANG CHEM (HANGZHOU) CO.,LTD 58
Amadis Chemical Company Limited 58
Beijing Dakco is Biotechnology Co., Ltd. 58
Beijing Xiangsheng Xingye Technology Co., Ltd. 58
Shenzhen Xinbosheng Biological Technology Co., Ltd. 58
Shanghai Boyi Biotechnology Co., Ltd. 58
Shanghai Jijin Chemical Technology Co., Ltd. 58
Beijing Baiao Innovation Technology Co., Ltd. 58

175178-82-2(AG 1478)Related Search:

Adapalene ZM 336372 (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Sunitinib Malate RANAKININ
NS-398 AG 213 Quinazoline AG 1478 in Solution AG1478HCl,AG-1478,AG 1478 HYDROCHLORIDE
Tyrphostin AG 1478 (4-(3-Chloroanilino)-6, 7-dimethoxyquinazoline) AG 1478 EPIDERMAL GROWTH FACT TYRPHOSTIN A51 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) AG 1295
chevron_left

1of3

chevron_right
NSC 669364 N-[3-CHLOROPHENYL]-6,7-DIMETHOXY-4-QUINAZOLINAMINE N-(3-CHLOROPHENYL)-N-(6,7-DIMETHOXY-4-QUINAZOLINYL)AMINE SU 5271 WHI-P 79 TYRPHOSTIN AG 1478 TYRPHOSTIN AG 1517 AG 1478 AG 1517 4-(N-3-CHLOROPHENYL)-AMINO-6,7-DIMETHOXYQUINAZOLINE 4-QUINAZOLINAMINE, N-(3-BROMOPHENYL)-6,7-DIMETHOXY- 4-(3-BROMOPHENYLAMINO)-6,7-BIS(METHOXY)QUINAZOLINE 4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE 4-(3-BROMOPHENYLAMINO)-6,7-DIMETHYLQUINAZOLINE 4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE 4-(3-CHLOROANILLINO)-6,7-DIMETHOXYQUINAZOLINE 4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE COMPOUND 32 TYRPHOSTIN AG 1478, 99+% 4-(3-Chloro-benzyl)-6,7-dimethoxy-quinazoline 4-Quinazolinamine,N-(3-chlorophenyl)-6,7-dimethoxy- N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine Tyrphostin AG 1478, Methanesulfonate Salt InSolution? AG 1478 PD-153,035 Tyrphostin AG InSolution AG 1478 - CAS 175178-82-2 - Calbiochem AG 1478 - CAS 175178-82-2 - Calbiochem 4-[(3-chlorophenyl)methyl]-6,7-dimethoxyquinazoline AG 1478 USP/EP/BP AG 1478, EGF receptor tyrosine kinase inhibitor 175178-82-2 174178-82-2 BioChemical Cell Signaling and Neuroscience Cell Biology Kinase/Phosphatase Biology Epidermal Growth Factor Receptor (EGFR) Receptor Tyrosine Kinase Inhibitors