AG 957
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- Product name: AG 957
- CAS: 140674-76-6
- MF: C15H15NO4
- MW: 273.28
- EINECS:
- MDL Number:MFCD01074970
- Synonyms:Lavendustin C Analog, Methyl-4-[N-(2μ,5μ-dihydroxybenzyl)amino]benzoate;NSC 654705;TYRPHOSTIN 957;TYRPHOSTIN AG 957;AG 957;4-AMINO-N-(2,5-DIHYDROXYBENZYL)METHYL BENZOATE;LAVENDUSTIN C ANALOG;METHYL-4-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOATE
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Properties
Boiling point :504.2±45.0 °C(Predicted)
Density :1.337±0.06 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: soluble
form :crystalline solid
pka :10.30±0.43(Predicted)
color :Off-white to light brown
Density :1.337±0.06 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: soluble
form :crystalline solid
pka :10.30±0.43(Predicted)
color :Off-white to light brown
Safety Information
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Description
Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases. AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl), as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 μM, respectively, for human proteins). It also inhibits epidermal growth factor receptor (IC50 = 0.25 μM). As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line. AG957 is also used to study signaling through c-Abl.Related product price
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