TYRPHOSTIN AG 1024

₹13100
Product name: TYRPHOSTIN AG 1024
CAS: 65678-07-1
MF: C14H13BrN2O
MW: 305.17
EINECS:
MDL Number:MFCD02179365
Synonyms:2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile;AGS 200;Tyrphostin;2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile AGS 200;AG-1024;HY-10253; AG 1024; AGS 200;HY-10253;AG-1024 (Tyrphostin);2-(3-broMo-5-tert-butyl-4-hydroxybenzylidene)Malononitrile

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Sigma-Aldrich(India)

Package

ManufacturerSigma-Aldrich(India)
Product number121767
Product descriptionAG 1024 - CAS 65678-07-1 - Calbiochem A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kina
Packaging1MG
Price₹13100
Updated2022-06-14
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Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	121767	AG 1024 - CAS 65678-07-1 - Calbiochem A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kina	1MG	₹13100	2022-06-14	Buy

Properties

storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble
form :solid
color :yellow

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning		P264, P270, P301+P312, P330, P501

Precautionary statements:

P280	Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) initiates a cascade of reactions that promote cell growth and transformation by activating the PI3K/Akt signaling pathway, inhibiting apoptotic pathways, and mediating mitogenic actions. Overexpression of IGF-1R confers tumorigenic potential to cells as well as protection from apoptosis. AG-1024 is a selective inhibitor of IGF-1R that inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation with IC50 values of 0.4 and 7 μM, respectively. At 10 nM, AG-1024 can inhibit proliferation and induce apoptosis in human breast cancer MCF-7 cells, and it inhibits autocrine growth of human prostate cancer DU145 cells with an IC50 value of 2.5 μM.

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