TYRPHOSTIN AG 1024
![]() |
- ₹13100
- Product name: TYRPHOSTIN AG 1024
- CAS: 65678-07-1
- MF: C14H13BrN2O
- MW: 305.17
- EINECS:
- MDL Number:MFCD02179365
- Synonyms:2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile;AGS 200;Tyrphostin;2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile AGS 200;AG-1024;HY-10253; AG 1024; AGS 200;HY-10253;AG-1024 (Tyrphostin);2-(3-broMo-5-tert-butyl-4-hydroxybenzylidene)Malononitrile
1 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- ManufacturerSigma-Aldrich(India)
- Product number121767
- Product descriptionAG 1024 - CAS 65678-07-1 - Calbiochem A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kina
- Packaging1MG
- Price₹13100
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 121767 | AG 1024 - CAS 65678-07-1 - Calbiochem A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kina | 1MG | ₹13100 | 2022-06-14 | Buy |
Properties
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble
form :solid
color :yellow
solubility :DMSO: soluble
form :solid
color :yellow
Safety Information
Symbol(GHS): |
![]() |
||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | ||||||||||||||
Hazard statements: |
|
||||||||||||||
Precautionary statements: |
|
Description
The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) initiates a cascade of reactions that promote cell growth and transformation by activating the PI3K/Akt signaling pathway, inhibiting apoptotic pathways, and mediating mitogenic actions. Overexpression of IGF-1R confers tumorigenic potential to cells as well as protection from apoptosis. AG-1024 is a selective inhibitor of IGF-1R that inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation with IC50 values of 0.4 and 7 μM, respectively. At 10 nM, AG-1024 can inhibit proliferation and induce apoptosis in human breast cancer MCF-7 cells, and it inhibits autocrine growth of human prostate cancer DU145 cells with an IC50 value of 2.5 μM.More related product prices
Olaparib BMS-754807 Rapamycin LY 294002 HYDROCHLORIDE AVP-AEW541 OSI-906 AG 957 TYRPHOSTIN B56 TYRPHOSTIN AG 1296 TYRPHOSTIN AG 879Related product price
- Rapamycin
₹4194-370089 - LY 294002 HYDROCHLORIDE
₹10660-37350 - AVP-AEW541
₹19247.4-77355.9