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TYRPHOSTIN AG 1024

TYRPHOSTIN AG 1024 Structure
CAS No.
65678-07-1
Chemical Name:
TYRPHOSTIN AG 1024
Synonyms
CS-241;AGS 200;HY-10253;Tyrphostin;AG-1024 (Tyrphostin);AG1024; TYRPHOSTIN AG 1024;TYRPHOSTIN AG 1024 USP/EP/BP;AG-1024;TYRPHOSTIN AG1024;AGS 200;AG-1024;HY-10253; AG 1024; AGS 200;AG 1024 - CAS 65678-07-1 - Calbiochem
CBNumber:
CB5505050
Molecular Formula:
C14H13BrN2O
Molecular Weight:
305.17
MOL File:
65678-07-1.mol
MSDS File:
SDS
Modify Date:
2023/9/20 16:43:00
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TYRPHOSTIN AG 1024 Properties

storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO: soluble
form solid
color yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Safety Statements  22-24/25
WGK Germany  3

TYRPHOSTIN AG 1024 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 121767 AG 1024 - CAS 65678-07-1 - Calbiochem A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kina 65678-07-1 1MG ₹13100 2022-06-14 Buy
Product number Packaging Price Buy
121767 1MG ₹13100 Buy

TYRPHOSTIN AG 1024 Chemical Properties,Uses,Production

Description

The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) initiates a cascade of reactions that promote cell growth and transformation by activating the PI3K/Akt signaling pathway, inhibiting apoptotic pathways, and mediating mitogenic actions. Overexpression of IGF-1R confers tumorigenic potential to cells as well as protection from apoptosis. AG-1024 is a selective inhibitor of IGF-1R that inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation with IC50 values of 0.4 and 7 μM, respectively. At 10 nM, AG-1024 can inhibit proliferation and induce apoptosis in human breast cancer MCF-7 cells, and it inhibits autocrine growth of human prostate cancer DU145 cells with an IC50 value of 2.5 μM.

Uses

Tyrphostin AG 1024 is an insulin-like growth factor (IGF)-I receptor antagonist.

TYRPHOSTIN AG 1024 Preparation Products And Raw materials

Raw materials

Preparation Products

TYRPHOSTIN AG 1024 Suppliers

Global( 94)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
Coresyn Pharmatech Co., Ltd. +86-571-86626709 +86-18157142896 China 9991 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
LEAP CHEM CO., LTD. 58
Coresyn Pharmatech Co., Ltd. 58

TYRPHOSTIN AG 1024 Spectrum

TYRPHOSTIN AG 1024(65678-07-1)1HNMR

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2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile AGS 200 Tyrphostin 2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile AGS 200 AG-1024;HY-10253; AG 1024; AGS 200 HY-10253 AG-1024 (Tyrphostin) 2-(3-broMo-5-tert-butyl-4-hydroxybenzylidene)Malononitrile AG1024; TYRPHOSTIN AG 1024 AG 1024 - CAS 65678-07-1 - Calbiochem CS-241 AG-1024;TYRPHOSTIN AG1024;AGS 200 Propanedinitrile, 2-[[3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]- TYRPHOSTIN AG 1024 USP/EP/BP AG-1024 Selective IGF-1R inhibitor AG1024 IGF-1R,IGF1R,DNA-PKcs,phosphorylation,growth,AG1024,Apoptosis,Tyrphostin AG1024,Tyrphostin AG-1024,AG-1024,BCR-ABL,AG 1024,factor-1,Insulin Receptor,anti-cancer,Inhibitor,Akt,inhibit 65678-07-1