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TYRPHOSTIN AG 1296

TYRPHOSTIN AG 1296 Structure
CAS No.
146535-11-7
Chemical Name:
TYRPHOSTIN AG 1296
Synonyms
1296;AG 1296;AG-1296;AG 1296;;TYRPHOSTIN AG 1296;TYRPHOSTIN AG 1296 USP/EP/BP;Tyrphostin AG 1296 (AG 1296);AG-1296 (Tyrphostin AG 1296);6,7-DIMETHOXY-3-PHENYLQUINOXALINE;6,7-DIMETHOXY-2-PHENYLQUINOXALINE;Quinoxaline,6,7-dimethoxy-2-phenyl-
CBNumber:
CB7435034
Molecular Formula:
C16H14N2O2
Molecular Weight:
266.29
MOL File:
146535-11-7.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:01:57

TYRPHOSTIN AG 1296 Properties

Boiling point 420.2±40.0 °C(Predicted)
Density 1.192±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility Soluble in DMSO.
pka 0.48±0.30(Predicted)
form White solid
color Yellow
Sensitive Light Sensitive
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3
NFPA 704
0
2 0

TYRPHOSTIN AG 1296 Chemical Properties,Uses,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1296 is a potent and selective inhibitor of PDGF receptor kinase with an IC50 value of about 0.4 μM both in vitro and in cells (Swiss 3T3 cells). It inhibits ligand-stimulated DNA synthesis in platelet-derived growth factor receptor and stem cell factor/kit receptor transfected cells with an IC50 values of 1.5 and 1.8 μM, respectively. Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype.

Uses

Tyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.

TYRPHOSTIN AG 1296 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 99)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd +86-86-22-87899925 +86-8618522618860 China 694 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry

TYRPHOSTIN AG 1296 Spectrum

TYRPHOSTIN AG 1296 AG 1296 6,7-DIMETHOXY-2-PHENYLQUINOXALINE 6,7-DIMETHOXY-3-PHENYLQUINOXALINE Quinoxaline,6,7-dimethoxy-2-phenyl- AG-1296;AG 1296; AG 1296 - CAS 146535-11-7 - Calbiochem AG-1296 (Tyrphostin AG 1296) Tyrphostin AG 1296 (AG 1296) 1296 TYRPHOSTIN AG 1296 USP/EP/BP Fms like tyrosine kinase 3,PDGF,Apoptosis,CD117,inhibit,platelet-derived,CD135,SCFR,Tyrphostin AG-1296,c-Kit,PDGFR,FLT3,cell,AG1296,growth,stem,Inhibitor,Tyrphostin AG1296,Cluster of differentiation antigen 135,AG-1296,factor,Platelet-derived growth factor receptor 146535-11-7 BioChemical Cell Biology Cell Signaling and Neuroscience Receptor Tyrosine Kinase Inhibitors Platelet Derived Growth Factor Receptor (PDGFR) Kinase/Phosphatase Biology Inhibitors