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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Angiogenesis >FGFR inhibitor >AZD-4547

AZD-4547

AZD-4547 Structure
CAS No.
1035270-39-3
Chemical Name:
AZD-4547
Synonyms
CS-21;AZD-4547;13C6]-AZD4547;AZD4547, >=98%;AZD4547/AZD-4547;AZD4547, Free Base, >99%;AZD4547 FGFR inhibitor AZD-4547;AZD4547, 98%, a potent inhibitor of the FGFR family;N-(3-(3,5-dimethoxyphenethyl)-1H-pyrazol-5-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide;N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-3,5-dimethylpiperazin-1-yl)benzamide
CBNumber:
CB92546547
Molecular Formula:
C26H33N5O3
Molecular Weight:
463.57
MOL File:
1035270-39-3.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

AZD-4547 Properties

Melting point 168-170°C
Boiling point 621.7±55.0 °C(Predicted)
Density 1.189
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
pka 13.66±0.10(Predicted)
form Solid
color Pale Yellow to Light Beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS06
Signal word  Danger
Hazard statements  H372-H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P314-P501
NFPA 704
0
2 0

AZD-4547 Chemical Properties,Uses,Production

Description

AZD 4547 is a selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinase with IC50 values of 0.2, 2.5, and 1.8 nM for FGFR1, 2, and 3, respectively. It displays weaker activity against FGFR4 (IC50 = 165 nM), VEGFR2 (IC50 = 24 nM), and a panel of other tyrosine and serine/theronine kinases such as insulin-like growth factor 1 receptor (IC50 = 581 nM), cyclin-dependent kinase 2 (IC50 = >10 μM), and p38 (IC50 = >100 μM). AZD 4547 has demonstrated antiproliferative activity in tumor cell lines expressing deregulated FGFRs (IC50s = 18-281 nM). In an FGFR-driven human tumor xenograft mouse model, oral administration of AZD 4547 at concentrations up to 12.5 mg/kg/day resulted in potent dose-dependent antitumor activity.

Chemical Properties

Pale Yellow Solid

Uses

AZD4547 is a bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinases. AZD4547 is particularly effective in inhibiting FGFR1, 2, and 3 tyrosine k inases and is under clinical investigation for the treatment of FGFR-dependent tumors.

AZD-4547 Preparation Products And Raw materials

Raw materials

Preparation Products

AZD-4547 Suppliers

Global( 188)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418684 +8618949823763 China 25363 58 Inquiry
Coresyn Pharmatech Co., Ltd. +86-571-86626709 +86-18157142896 China 9991 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
Coresyn Pharmatech Co., Ltd. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58

AZD-4547 Spectrum

AZD-4547(1035270-39-3)1HNMR

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AZD-4547 rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide AZD4547/AZD-4547 AZD4547, Free Base, >99% rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide AZD4547 N-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-rel-3,5-dimethylpiperazin-1-yl)benzamide rel-N-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-3,5-dimethylpiperazin-1-yl)benzamide AZD4547, >=98% rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benz AZD-4547;REL-N-[5-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-3-YL]-4-[(3R,5S)-3,5-DIMETHYL-1-PIPERAZINYL]BENZAMIDE;AZD4547/AZD-4547;AZD4547, FREE BASE, >99%;REL-N-[5-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-3-YL]-4-[(3R,5S)-3,5-DIMETHYL-1-PIPERAZINYL]BENZ CS-21 N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide N-(3-(3,5-dimethoxyphenethyl)-1H-pyrazol-5-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide Benzamide, N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-, rel- AZD4547, 98%, a potent inhibitor of the FGFR family N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-3,5-dimethylpiperazin-1-yl)benzamide 13C6]-AZD4547 AZD4547 FGFR inhibitor AZD-4547 1035270-39-3 C26H33N5O3 Inhibitors Anti-cancer&immunity API