ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Tyrosine derivatives >AG 490
AG 490
- CAS No.
- 133550-30-8
- Chemical Name:
- AG 490
- Synonyms
- AG 49;AG 490;CS-316;AG490,AG-490;Zinc02557947;zinc0255794);AG 490, >=98%;TYRPHOSTIN B42;TYROPHOSTIN AG490;TYRPHOSTIN AG 490
- CBNumber:
- CB4779212
- Molecular Formula:
- C17H14N2O3
- Molecular Weight:
- 294.3
- MOL File:
- 133550-30-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/10/7 17:44:49
| Melting point | 215°C(lit.) |
|---|---|
| Boiling point | 615.2±55.0 °C(Predicted) |
| Density | 1.337 |
| storage temp. | -20°C |
| solubility | ethanol: 5 mg/mL |
| form | solid |
| pka | 8.75±0.10(Predicted) |
| color | yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month. |
| InChIKey | TUCIOBMMDDOEMM-ZSOIEALJSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H400 | |||||||||
| Precautionary statements | P273-P301+P310 | |||||||||
| Hazard Codes | Xi,N,T | |||||||||
| Risk Statements | 36/37/38-50-25 | |||||||||
| Safety Statements | 26-36-61-45 | |||||||||
| RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | UC6316197 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269090 | |||||||||
| NFPA 704 |
|
AG 490 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T3434 | Tyrphostin AG 490 solid | 133550-30-8 | 5MG | ₹10640.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T3434 | Tyrphostin AG 490 solid | 133550-30-8 | 25MG | ₹43126.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 658401 | AG 490 - CAS 133550-30-8 - Calbiochem A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC?? = 100 n | 133550-30-8 | 5MG | ₹5880 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T2962 | Tyrphostin AG 490 | 133550-30-8 | 20MG | ₹3800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T2962 | Tyrphostin AG 490 | 133550-30-8 | 100MG | ₹8800 | 2022-05-26 | Buy |
AG 490 Chemical Properties,Uses,Production
Uses
AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8 μM for EGFR and JAK, respectively.
Biological Activity
Selective inhibitor of EGF receptor tyrosine kinase (IC 50 values are 2 and 13.5 μ M for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo .
Biochem/physiol Actions
Jak-2 protein tyrosine kinase (PTK) inhibitor. Inhibits interleukin 2 (IL-2) driven mitogenesis and triggers apoptosis of tumor cells in Sezary syndrome, a leukemic variant of cutaneous T cell lymphoma.
AG 490 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 162)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12458 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
133550-30-8(AG 490)Related Search:
Zinc02557947
AG-490 (Tyrphostin B42)
(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide AG-490(Tyrphostin B42)
Tyrphostin AG 490
AG 490
AG 490, >=98%
(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
AG490,AG-490
2-CYANO-3-[3,4-DIHYDROXYPHENYL]-N-[PHENYLMETHYL]-2-PROPENAMIDE
N-BENZYL-3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE
N-BENZYL-3,4-DIHYDROXY-BENZYLIDENECYANOACETAMIDE
TYROPHOSTIN AG490
TYRPHOSTIN AG 490
TYRPHOSTIN B42
2-cyano-3-(3,4-dihydroxyphenyl)-n-(benzyl)-2-propenamide
bis-tyrphostin B42
AG 490 (Tyrphostin AG 490)
N-Benzyl-2-cyano-3-(3,4-dihydroxy-phenyl)-acrylamide
(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
AG 490(Tyrphostin AG 490,Tyrphostin B42)
2-PropenaMide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylMethyl)-, (2E)-
(E)-2-CYANO-3-(3,4-DIHYDROPHENYL)-N-(PHENYLMETHYL)-2-PROPENAMIDE
A-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMAMIDE
A-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE
AG 490
ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE
AG-490, 99%, an inhibitor of EGFR
0 Tyrphostin AG 490
AG490(Tyrphostin )
zinc0255794)
TIANFU-CHEM AG 490
AG 490;TYRPHOSTIN AG 490;AG490;ZINC02557947;AG-490 (TYRPHOSTIN B42)
CS-316
AG 490 - CAS 133550-30-8 - Calbiochem
Tyrphostin B42 (AG-490)
Tyrphostin AG490 AG-490 JAK-2 specific inhibitor
Epidermal growth factor receptor,Inhibitor,Tyrphostin AG490,Tyrphostin B-42,ErbB-1,STAT,Janus kinase,AG490,Autophagy,Tyrphostin B 42,EGFR,HER1,inhibit,Tyrphostin AG-490,JAK
AG 49
133550-30-8
Cell Signaling and Neuroscience
Cell Biology
BioChemical
Non-Receptor Tyrosine Kinase Inhibitors
Kinase/Phosphatase Biology
Janus Kinase (JAK)
Intracellular Signaling
Inhibitors
Inhibitor
Protein Kinase