ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Protein tyrosine kinase /JAK / STAT >STAT inhibitors >Stattic
Stattic
- CAS No.
- 19983-44-9
- Chemical Name:
- Stattic
- Synonyms
- Stattic;CS-1523;AKOS 1001;15-Methyl-PGF2α;BUTTPARK 97\04-73;STAT3 Inhibitor V;Stattic USP/EP/BP;Stat3 inhibitor V, stattic;Stat three inhibitory compound;15(S)-15-Methyl Prostaglandin F2α
- CBNumber:
- CB7294835
- Molecular Formula:
- C8H5NO4S
- Molecular Weight:
- 211.19
- MOL File:
- 19983-44-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 187-188 °C |
|---|---|
| Boiling point | 461.1±45.0 °C(Predicted) |
| Density | 1.621±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: >20mg/mL |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
Stattic price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S7947 | Stattic ≥98% (HPLC), powder | 19983-44-9 | 25MG | ₹16259.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 573099 | STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents it | 19983-44-9 | 25MG | ₹31190 | 2022-06-14 | Buy |
Stattic Chemical Properties,Uses,Production
Uses
Stattic is a Stat3 inhibitor which exhibited potent anti-tumor and induced chemo- and radio-sensitivity in nasopharyngeal carcinoma.
Biological Activity
Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.
Biochem/physiol Actions
Stattic (Stat3 three inhibitory compound) alters the SH2 domain of Stat3 and indirectly inhibits with phosphopeptide binding. It is readily transported across the cell membrane compared to other phosphopeptides.2 Stattic induces increased formation of ROS and negatively affects the cardiomyocyte mitochondrial function,3 and sensitizes nasopharyngeal carcinoma cells to chemoradiotherapy.4
Stattic Preparation Products And Raw materials
Global( 155)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
| Shanghai Safer Pharmaceutical Technology Co., Ltd. | 021-31761238 | CHINA | 897 | 58 | Inquiry |
| Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | CHINA | 272 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24099 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
19983-44-9(Stattic)Related Search:
BUTTPARK 97\04-73
6-NITRO-1H-1LAMBDA6-BENZO[B]THIOPHENE-1,1-DIONE
AKOS 1001
6-Nitro-1-benzothiophene 1,1-dioxide
1,1-DIOXO-6-NITROBENZO(B)THIOPHENE
6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
Stattic
6-Nitrobenzo[b]thiophene1,1-dioxide
Benzo[b]thiophene, 6-nitro-, 1,1-dioxide
Stat three inhibitory compound
Stat3 inhibitor V, stattic
1,1-Dioxide-6-nitro-benzo[b]thiophene
STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem
CS-1523
STAT3 Inhibitor V
Stattic USP/EP/BP
6-Nitro-benzo[b]thiophen-1,1-dioxid
15(S)-15-Methyl Prostaglandin F2α
15-Methyl-PGF2α
19983-44-9
C8H5NO4S
Inhibitors
JAK
STAT
JAK/STAT