Cryptotanshinone
- CAS No.
- 35825-57-1
- Chemical Name:
- Cryptotanshinone
- Synonyms
- CRYPTOTANSHINONE;Cryptotanshinon;Cryptotanshinone, Tanshinone c;CS-1284;98% BY HPLC;Tanshinone c;Cryptotanshine;Noncrystalline;yindanshentong;Crypttanshinone
- CBNumber:
- CB4222031
- Molecular Formula:
- C19H20O3
- Molecular Weight:
- 296.36
- MOL File:
- 35825-57-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 192°C(lit.) |
|---|---|
| Boiling point | 459.0±45.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥5mg/mL |
| form | powder |
| color | orange-brown |
| optical activity | [α]/D -85.0±3.0°, c = 0.1 in chloroform |
| λmax | 263nm(lit.) |
| BRN | 5445400 |
| InChIKey | IJSBKZLSTIFYIE-FPKDZHNTSA-N |
| LogP | 4.130 (est) |
| CAS DataBase Reference | 35825-57-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H410 | |||||||||
| Precautionary statements | P273-P301+P310-P501 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 25-50/53 | |||||||||
| Safety Statements | 45-60-61 | |||||||||
| RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SF8282645 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29321900 | |||||||||
| NFPA 704 |
|
Cryptotanshinone price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C5624 | Cryptotanshinone ≥98% (HPLC) | 35825-57-1 | 5MG | ₹7620.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C5624 | Cryptotanshinone ≥98% (HPLC) | 35825-57-1 | 25MG | ₹25720.2 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C3363 | Cryptotanshinone | 35825-57-1 | 25MG | ₹4400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C3363 | Cryptotanshinone | 35825-57-1 | 100MG | ₹8000 | 2022-05-26 | Buy |
Cryptotanshinone Chemical Properties,Uses,Production
Chemical Properties
Orange powder
Uses
inhibits angiogenesis
General Description
Cryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 μM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 μM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 μM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).
Biological Activity
Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC 50 = 4.6 μ ). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC 50 = 4.09 μ ) and reduction in A β peptide generation.
Cytotoxicity
IC50 (μg/mL): 1.27 (A549), 1.39 (TOV-21G) (Chang et al. 2013)
Cryptotanshinone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16208 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860 +86-18080483897 | China | 3424 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |