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illudin S

illudin S Structure
CAS No.
1149-99-1
Chemical Name:
illudin S
Synonyms
CS-1385;Illudin;Lampterol;Illusin S;Lunamycin;illudin S;NSC 400979;Illudine S;NSC-626369;(1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1'-cyclopropane]-4-one
CBNumber:
CB91318110
Molecular Formula:
C15H20O4
Molecular Weight:
264.32
MOL File:
1149-99-1.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:40
Request For Quotation

illudin S Properties

Melting point 124-126℃
Boiling point 327.55°C (rough estimate)
Density 1.0583 (rough estimate)
refractive index 1.4300 (estimate)
storage temp. -20°C, Inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form A light yellow solid
pka 12.50±0.70(Predicted)
color Off-white to yellow

illudin S Chemical Properties,Uses,Production

Description

Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.

Uses

Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.

illudin S Preparation Products And Raw materials

Raw materials

Preparation Products

illudin S Suppliers

Global( 72)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Fuxin Pharmaceutical +86-021-021-50872116 +8613122107989 China 10297 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Shanghai Minbiotech Co., Ltd. +8617315815539 CHINA 129 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Henan Alfa Chemical Co., Ltd +8618339805032 China 13096 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
BOC Sciences 58
Fuxin Pharmaceutical 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
TargetMol Chemicals Inc. 58
Shanghai Minbiotech Co., Ltd. 58
AFINE CHEMICALS LIMITED 58
Henan Alfa Chemical Co., Ltd 58
Nantong HI-FUTURE Biology Co., Ltd. 58
LEAPCHEM CO., LTD. 58

illudin S Spectrum

illudin S(1149-99-1)1HNMR

1149-99-1(illudin S)Related Search:

PROTOPANAXDIOL Lupeol Quillaic acid Cryptochlorogenic acid Cryptotanshinone
DEMETON S illudin M (S)-1-CYCLOPROPYLETHANOL FEMA 3766 1-CYCLOPROPYL-PROPAN-2-ONE
3-METHYL-3-CYCLOHEXEN-1-ONE 2,2,4,6,6-PENTAMETHYL-3-HEPTENE illudin S 1-CYCLOPROPYL-1-METHYLETHANOL 3,5,5-trimethylcyclohex-3-en-1-one
1-(1-METHYLCYCLOPROPYL)ACETONE ISO-PROPENYLCYCLOPROPANE
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illudin S (2'S,3'R,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2'-hydroxymethyl-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one Illusin S Lampterol NSC-626369 Illudin Illudine S Lunamycin NSC 400979 (1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1'-cyclopropane]-4-one CS-1385 Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-, (2'S,3'R,6'R)- 1149-99-1 ADC