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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Protein tyrosine kinase /JAK / STAT >STAT inhibitors >S3I-201

S3I-201

S3I-201 Structure
CAS No.
501919-59-1
Chemical Name:
S3I-201
Synonyms
CS-450;106202;S2I-201;S31-201;S3I-201;NSC 74859;S3I-201, >98%;NSC 74859, >=98%;S3I-201 USP/EP/BP;NSC 74859(S31-201)
CBNumber:
CB22452397
Molecular Formula:
C16H15NO7S
Molecular Weight:
365.36
MOL File:
501919-59-1.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

S3I-201 Properties

Melting point >185oC (dec.)
Boiling point 654.7±55.0 °C(Predicted)
Density 1.507
storage temp. -20°C
solubility DMSO: >10mg/mL
pka 2.98±0.10(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
WGK Germany  3

S3I-201 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0330 S3I-201 ≥97% (HPLC) 501919-59-1 5MG ₹11268.83 2022-06-14 Buy
Sigma-Aldrich(India) SML0330 S3I-201 ≥97% (HPLC) 501919-59-1 25MG ₹46038.73 2022-06-14 Buy
Sigma-Aldrich(India) 573102 STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem STAT3 Inhibitor VI, S3I-201, CAS 501919-59-1, is a cell-permeable compound that binds Stat3-SH2 domain and blocks Stat3 phosphorylation, dimerization, 501919-59-1 10MG ₹14260 2022-06-14 Buy
Sigma-Aldrich(India) 573102 STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem STAT3 Inhibitor VI, S3I-201, CAS 501919-59-1, is a cell-permeable compound that binds Stat3-SH2 domain and blocks Stat3 phosphorylation, dimerization, 501919-59-1 25MG ₹22650 2022-06-14 Buy
Product number Packaging Price Buy
SML0330 5MG ₹11268.83 Buy
SML0330 25MG ₹46038.73 Buy
573102 10MG ₹14260 Buy
573102 25MG ₹22650 Buy

S3I-201 Chemical Properties,Uses,Production

Uses

S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:

  • to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)
  • to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines
  • to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells

Definition

ChEBI: An amidobenzoic acid obtained by formal condensation of the carboxy group of [(4-methylbenzene-1-sulfonyl)oxy]acetic acid with the amino group of 4-amino-2-hydroxybenzoic acid.

Biochem/physiol Actions

S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.

S3I-201 Preparation Products And Raw materials

Raw materials

Acetyl chloride, 2-[[(4-methylphenyl)sulfonyl]oxy]- Ethyl (p-tosyloxy)acetate 2-(p-Toluenesulfonyloxy)acetic Acid Tosyl chloride

Preparation Products

S3I-201 Suppliers

Global( 134)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Henan Alfa Chemical Co., Ltd +8618339805032 China 13096 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
CHEMSWORTH 30
A.J Chemicals 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
Henan Alfa Chemical Co., Ltd 58

S3I-201 Spectrum

S3I-201(501919-59-1)1HNMR

501919-59-1(S3I-201)Related Search:

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2-Pyridinecarbothioamide, N-2-pyridinyl- 1,3-Bis(4-aminophenyl)urea 5-(4-iodobenzylidene)rhodanine NSC228155 NSC632839hydrochloride
NSC23005 Sodium HAMNO NSC 247030 5-[(4-chlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione Fludarabine
Stattic Dasatinib NSC781406
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S2I-201 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid NSC 74859(S3I-201) 2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid Stat3 Inhibitor I, S3I-201 OTAVA-BB 7070707021 S31-201 (NSC 74859) NSC 74859, >=98% OTAVA-BB 7070707021S31-201 (NSC 74859)，S3I-201 Stat3 Inhibitor VI, S3I-201 S3I-201, 501919-59-1 S31-201 2-hydroxy-4-(2-(tosyloxy)acetaMido)benzoic acid NSC 74859 (S3I-201) NSC 74859 S3I-201 S3I-201 (NSC 74859) 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid S3I201; NSC74859; NSC 74859;NSC-74859; S3I 201 S3I-201, >98% S3I201; NSC74859; NSC 74859; S3I 201 CS-450 STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem NSC 74859(S31-201) 106202 Benzoic acid, 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]- S3I-201 USP/EP/BP STAT3 Inhibitor VI S3I-201 NSC74859 NSC-74859 501919-59-1 Inhibitors JAK STAT