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NSC781406

NSC781406 Structure
CAS No.
1676893-24-5
Chemical Name:
NSC781406
Synonyms
NSC781406;NSC-781406;NSC 781406;NSC781406;NSC-781406;NSC 781406;NSC781406,Phosphoinositide 3-kinase,NSC 781406,NSC-781406,PI3K,Mammalian target of Rapamycin,Inhibitor,inhibit,mTOR;Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]-
CBNumber:
CB43334188
Molecular Formula:
C29H27F2N5O5S2
Molecular Weight:
627.68
MOL File:
1676893-24-5.mol
Modify Date:
2024/7/2 8:55:08
Request For Quotation

NSC781406 Properties

Boiling point 775.1±70.0 °C(Predicted)
Density 1.52±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
form A solid
pka 6.23±0.40(Predicted)
color White to off-white

NSC781406 Chemical Properties,Uses,Production

Description

NSC 781406 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR; IC50s = 2.0, 9.4, 2.7, 14, and 5.4 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR, respectively). It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 65 nM). NSC 781406 (30 mg/kg) reduces tumor volume in a BEL-7404 hepatic cancer mouse xenograft model.

NSC781406 Preparation Products And Raw materials

Raw materials

Preparation Products

NSC781406 Suppliers

Global( 34)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9274 58 Inquiry
Chunchuang (Wuhan) Technology Co., Ltd 15342225168 China 10005 58 Inquiry
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 China 9929 58 Inquiry
InvivoChem 13549236410 China 6747 58 Inquiry
Kaifeng Mingren Pharmaceutical Co.,LTD 0371-65741762 China 2380 58 Inquiry
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 China 8011 62 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
InvivoChem 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Shanghai Chaolan Chemical Technology Center 58
InvivoChem 58
Kaifeng Mingren Pharmaceutical Co.,LTD 58
ShangHai Biochempartner Co.,Ltd 62

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NSC781406 NSC781406;NSC-781406;NSC 781406 NSC-781406;NSC 781406 Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]- NSC781406,Phosphoinositide 3-kinase,NSC 781406,NSC-781406,PI3K,Mammalian target of Rapamycin,Inhibitor,inhibit,mTOR 1676893-24-5 C29H27F2N5O5S2