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CP671305

CP671305 Structure
CAS No.
445295-04-5
Chemical Name:
CP671305
Synonyms
CS-2886;CP671305;UNII-9LH034R9R9;CP-671305; CP 671305; CP671305; UNII-9LH034R9R9;445295-04-5;CP 671305,Inhibitor,Phosphodiesterase (PDE),CP671305,CP-671305,inhibit;(R)-2-(4-((2-(benzo[d][1,3]dioxol-5-yloxy)nicotinamido)methyl)-3-fluorophenoxy)propanoic acid;Propanoic acid, 2-[4-[[[[2-(1,3-benzodioxol-5-yloxy)-3-pyridinyl]carbonyl]amino]methyl]-3-fluorophenoxy]-, (2R)-
CBNumber:
CB53175535
Molecular Formula:
C23H19FN2O7
Molecular Weight:
454.4
MOL File:
445295-04-5.mol
Modify Date:
2024/7/2 8:55:11
Request For Quotation

CP671305 Properties

storage temp. Store at -20°C
solubility DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): 2 mg/ml
form A crystalline solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

CP671305 Chemical Properties,Uses,Production

Description

CP 671,305 is a potent inhibitor of phosphodiesterase 4D (PDE4D; IC50 = 3 nM). It is selective for PDE4D over PDE4A, -B, and -C (IC50s = 310, 287, and 3,858 nM, respectively), as well as over PDE1-3 and 5 (IC50s = >5,000 nM for all). CP 671,305 inhibits release of leukotriene E4 (LTE4; ) from eosinophils (IC50 = 52 nM) and LTB4 from neutrophils (IC50 = 106 nM). In vivo, CP 671,305 inhibits antigen-induced pulmonary eosinophil influx in cynomolgus monkeys in a dose-dependent manner.

CP671305 Preparation Products And Raw materials

Raw materials

Preparation Products

CP671305 Suppliers

Global( 38)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Kaifeng Mingren Pharmaceutical Co.,LTD 0371-65741762 China 2380 58 Inquiry
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 17771424646 China 966 58 Inquiry
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 China 2988 58 Inquiry
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 China 8012 62 Inquiry
Shanghai Hansi Chemical Industry Co., Ltd. 17717618050 China 10424 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24017 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
InvivoChem 58
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Kaifeng Mingren Pharmaceutical Co.,LTD 58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 58
Shanghai Rechem science Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Shanghai Hansi Chemical Industry Co., Ltd. 58
TargetMol Chemicals Inc. 58

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HAMNO NSC 247030 NSC 42834
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CP671305 CP-671305; CP 671305; CP671305; UNII-9LH034R9R9;445295-04-5 UNII-9LH034R9R9 CS-2886 Propanoic acid, 2-[4-[[[[2-(1,3-benzodioxol-5-yloxy)-3-pyridinyl]carbonyl]amino]methyl]-3-fluorophenoxy]-, (2R)- (R)-2-(4-((2-(benzo[d][1,3]dioxol-5-yloxy)nicotinamido)methyl)-3-fluorophenoxy)propanoic acid CP 671305,Inhibitor,Phosphodiesterase (PDE),CP671305,CP-671305,inhibit 445295-04-5 API