1,9-Pyrazoloanthrone
- CAS No.
- 129-56-6
- Chemical Name:
- 1,9-Pyrazoloanthrone
- Synonyms
- SP600125;pyrazolanthrone;1PMV;JNKII;CS-548;Nsc75890;Anthra H;c.i.70300;Pyrazoxanone;SP600125 >99%
- CBNumber:
- CB6354608
- Molecular Formula:
- C14H8N2O
- Molecular Weight:
- 220.23
- MOL File:
- 129-56-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/25 20:17:06
| Melting point | 281~282℃ |
|---|---|
| Boiling point | 361.16°C (rough estimate) |
| Density | 1.1702 (rough estimate) |
| refractive index | 1.5910 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: insoluble |
| form | Yellowish orange solid |
| pka | 11.75±0.20(Predicted) |
| color | yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| InChIKey | ACPOUJIDANTYHO-UHFFFAOYSA-N |
| CAS DataBase Reference | 129-56-6(CAS DataBase Reference) |
| EPA Substance Registry System | Anthra[1,9-cd]pyrazol-6(2H)-one (129-56-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CB4585000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | LD50 ivn-mus: 178 mg/kg CSLNX* NX#00640 | |||||||||
| NFPA 704 |
|
1,9-Pyrazoloanthrone price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S5567 | SP600125 ≥98% (HPLC) | 129-56-6 | 10MG | ₹15100.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 420119 | JNK Inhibitor II - CAS 129-56-6 - Calbiochem JNK Inhibitor II. SP600125, CAS 129-56-6, is a potent, cell-permeable, selective, and ATP competitive inhibitor of c-Jun N-terminal kinase (JNK; IC?? | 129-56-6 | 5MG | ₹9909.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S5567 | SP600125 ≥98% (HPLC) | 129-56-6 | 50MG | ₹60295.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 420119 | JNK Inhibitor II - CAS 129-56-6 - Calbiochem JNK Inhibitor II. SP600125, CAS 129-56-6, is a potent, cell-permeable, selective, and ATP competitive inhibitor of c-Jun N-terminal kinase (JNK; IC?? | 129-56-6 | 25MG | ₹29890 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 420119 | JNK Inhibitor II - CAS 129-56-6 - Calbiochem JNK Inhibitor II. SP600125, CAS 129-56-6, is a potent, cell-permeable, selective, and ATP competitive inhibitor of c-Jun N-terminal kinase (JNK; IC?? | 129-56-6 | 50MG | ₹37350 | 2022-06-14 | Buy |
1,9-Pyrazoloanthrone Chemical Properties,Uses,Production
Uses
A broad-spectrum serine/threonine kinase inhibitor of JNK with an IC50 range from 40 to 90 nM.
Definition
ChEBI: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
General Description
A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.
Biological Activity
Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC 50 = 40-90 nM) with negligible activity at ERK2, p38 β and a range of enzymes (IC 50 > 10 μ M). Active in vivo . Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. Also available as part of the MAPK Inhibitor Tocriset™ .
Safety Profile
Poison by intravenous route.When heated to decomposition it emits toxic fumes ofNOx.
1,9-Pyrazoloanthrone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12447 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
| Shandong Deshang Chemical Co., Ltd. | +86-0531-8875-2665 +8613153039501 | China | 646 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | China | 8821 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |