Zolpidem
- CAS No.
- 82626-48-0
- Chemical Name:
- Zolpidem
- Synonyms
- Ivadal;Niotal;Edluar;CS-1159;ZOLPIDEM;Zoipidem;SL-80.0750;SL-80．0750-23N;Zolpidem (CRM);Stilnoct：Stilnox
- CBNumber:
- CB6345253
- Molecular Formula:
- C19H21N3O
- Molecular Weight:
- 307.39
- MOL File:
- 82626-48-0.mol
- Modify Date:
- 2023/6/8 9:02:48
| Melting point | 189-191°C |
|---|---|
| Density | 1.12±0.1 g/cm3(Predicted) |
| Flash point | 9℃ |
| storage temp. | Store at RT |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL |
| pka | 6.2(at 25℃) |
| form | solid |
| color | white |
| Water Solubility | <10mg/L(room temperature) |
| CAS DataBase Reference | 82626-48-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Zolpidem(82626-48-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H336-H411 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P273-P301+P312 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NJ5109750 | |||||||||
| HS Code | 2933996500 | |||||||||
| NFPA 704 |
|
Zolpidem Chemical Properties,Uses,Production
Description
Zolpidem hemitamwe is a non-benzodiazepine hypnotic with specific agonist activity at type 1 benzodiazepine receptors, and is indicated for use in insomnia and other sleep disorders. Structurally zolpidem belongs to a chemically distinct class, thus lacking the side-effects and abuse potential of classical benzodiazepines. It is currently being studied as a pre-operative sedative.
Chemical Properties
Off-White Solid
Uses
A selective benzodiazepine receptor agonist not related chemically to benzodiazepines
Definition
ChEBI: An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
General Description
Zolpidem (Ambien, an imidazopyridine) andeszopiclone (Lunesta, a cyclopyrrolone) are nonbenzodiazepinesand have been introduced as short- and moderate-acting hypnotics, respectively. Zolpidem exhibits ahigh selectivity for the α1 subunit of benzodiazepinebindingsite on GABAA receptor complex, whereas eszopicloneis a “superagonist” at BzRs with the subunitcomposition α1β2γ2 and α1β2γ3. Zolpidem has a rapidonset of action of 1.6 hours and good bioavailability(72%), mainly because it is lipophilic and has no ionizablegroups at physiological pH. Food can prolong the time topeak concentration without affecting the half-life probablyfor the same reason. It has short elimination half-life, becauseits aryl methyl groups is extensively α-hydroxylatedto inactive metabolites by CYP3A4 followed by furtheroxidation by aldehyde dehydrogenase to the ionic carboxylicacid. The metabolites are inactive, short-lived, andeliminated in the urine. Its half-life in the elderly or the patientswith liver disease is increased. Therefore, dosingshould be modified in patients with hepatic insufficiencyand the elderly. Because it has longer elimination half-lifethan zaleplon, it may be preferred for sleep maintenance.It was the most commonly prescribed drug for insomniain 2001.
Zolpidem Preparation Products And Raw materials
Raw materials
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